Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
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DOI：
10.1016/j.micinf.2016.10.008
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发表时间：
2017-03-01
影响因子：
5.8
通讯作者：
Deepe, George S., Jr.
中科院分区：
文献类型：
--
作者：
Friedrich, Dirk;Fecher, Roger A.;Deepe, George S., Jr.
人类病原真菌对不断变化的环境具有很强的适应性。适应低氧条件的能力对于宿主的定殖和感染至关重要。最近，哺乳动物缺氧诱导因子-1 α（HIF-1 α）对真菌免疫的影响已经出现。在这篇综述中，缺氧和HIF-1 α在真菌感染中的作用进行了讨论关于先天性免疫反应。(C)2016巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1 alpha (HIF-1 alpha) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1 alpha in fungal infections is discussed regarding the innate immune response. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.