Respiratory muscle and organ blood flow with inspiratory elastic loading and shock.
Respiratory muscle and organ blood flow with inspiratory elastic loading and shock.
复制标题
呼吸肌和器官血流量与吸气弹性负荷和冲击。
DOI：
10.1152/jappl.1985.58.4.1148
复制
发表时间：
1985
影响因子：
3.3
通讯作者：
C. Roussos
中科院分区：
文献类型：
--
作者：
S. Magder;D. Lockhat;B. Luo;C. Roussos
由于呼吸肌在血流不足时会衰竭，我们询问它们的血流是否会以其他重要器官（脑、心脏、肾、肠、脾）为代价维持在严重的水肿状态。我们测量了血流（放射性标记的微球）呼吸肌和重要器官在11只狗呼吸对吸气弹性负荷，首先与正常血压（BP），然后由心脏压塞产生的低血压。单纯弹性负荷时，血压和心输出量无明显变化;脑血流量（Qdi）从12.8 +/- 7.0增加到34.1 +/- 15.6 ml/100 g，总呼吸肌流量（QTR）从56.5 +/- 19.1增加到97.4 +/- 36.5 ml/100 g，但除脑外，流向其他器官的血流量没有变化。填塞后（平均BP = 79 +/- 16 mmHg），所有器官的血流均减少，而Qdi（39.0 +/- 19.4）无变化。QTR下降，但不显著，至88.6 +/- 49.5。随着更多的填塞（平均BP = 53 +/- 13 mmHg），所有重要器官的流量以及QTR（57.9 +/- 47.18）均降低，但Qdi并未显著降低，并且与正常BP的呼吸力具有相同的关系。因此，在严重吸气弹性负荷和严重低血压的情况下，膈肌和肋间外肌承担了大部分呼吸工作，它们的流动是以牺牲其他重要器官为代价的。
Since respiratory muscles fail when blood flow is inadequate, we asked whether their blood flow would be maintained in severe hypotensive states at the expense of other vital organs (brain, heart, kidney, gut, spleen). We measured blood flow (radiolabeled microspheres) to respiratory muscles and vital organs in 11 dogs breathing against an inspiratory elastic load, first with normal blood pressure (BP) and then hypotension produced by cardiac tamponade. With the elastic load alone, there was no change in BP or cardiac output; diaphragmatic blood flow (Qdi) increased from 12.8 +/- 7.0 to 34.1 +/- 15.6 ml/100 g, and total respiratory muscle flow (QTR) increased from 56.5 +/- 19.1 to 97.4 +/- 36.5 ml/100 g, but except for the brain, there was no change in blood flow to other organs. With tamponade (mean BP = 79 +/- 16 mmHg), flow decreased to all organs, whereas Qdi (39.0 +/- 19.4) did not change. QTR decreased, but not significantly, to 88.6 +/- 49.5. With more tamponade (mean BP = 53 +/- 13 mmHg), flow to all vital organs decreased as well as QTR (57.9 +/- 47.18), but Qdi did not significantly decrease and had the same relationship to respiratory force as with normal BP. Thus, with severe inspiratory elastic loading and severe hypotension, the diaphragm and external intercostal muscles did most of the respiratory work, and their flow was maintained at the expense of other vital organs.