In vitro microelectrode study of neuromuscular transmission in a case of botulism.
In vitro microelectrode study of neuromuscular transmission in a case of botulism.
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肉毒中毒病例中神经肌肉传递的体外微电极研究。
DOI：
10.1002/mus.880150303
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发表时间：
1992
期刊：
影响因子：
3.4
通讯作者：
Tonsgard,JH
中科院分区：
文献类型：
--
作者：
Maselli,RA;Burnett,ME;Tonsgard,JH
我们对一名6周龄肉毒梭菌毒素B中毒婴儿的肘肌活检进行了体外微电极研究。最显著的异常是终板电位（EPP）量子含量的严重减少和EPP潜伏期的显著变异。增加的可变性通常限于EPP的“单量子”成分。自发性微小终板电位（MEEP）的振幅和频率均未降低。然而，有一个广泛的振幅和频率的MEPP。这种独特的组合电生理学研究结果表明，神经肌肉传递的严重突触前失败，这似乎是由于在刺激诱导钙流入运动神经末梢后发生的突触囊泡释放过程的损害。
We performed in vitro microelectrode studies in the anconeus muscle biopsy of a 6‐week‐old infant intoxicated withClostridium botulinumtoxin B. The most striking abnormalities were the severe reduction of the endplate potential (EPP) quantal content and the marked variability of EPP latencies. The increased variability was often limited to a “single quantum” component of the EPP. Neither the amplitudes nor the frequencies of spontaneous miniature endplate potentials (MEEPs) were decreased. However, there was a wide range of amplitudes and frequencies of MEPPs. This unique combination of electrophysiologic findings indicates a severe presynaptic failure of neuromuscular transmission, which appears to result from an impairment of the process of synaptic vesicle release taking place after the stimulus induced influx of calcium into the motor nerve terminals.