Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities.
Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities.
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DOI：
10.1016/j.gde.2019.06.014
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发表时间：
2019-08
影响因子：
4
通讯作者：
Jessica L. Whited;M. Levin
中科院分区：
文献类型：
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作者：
Jessica L. Whited;M. Levin
细胞间的通讯是多细胞存在的基石。通过跨细胞膜的离子电导和通过组织空间传播电信号在细胞之间共享信息的古老机制是有效控制细胞决策和行为的强大手段。近年来，我们对细胞如何利用“生物电”信号的变化来引发系统水平的反应的理解有了极大的提高。我们现在不仅可以描述这些变化，而且还可以预测性地改变它们，以更多地了解它们对发育生物学和再生医学的重要性。最近的工作正在帮助研究人员构建一个更综合的观点，即这些简单的控制如何协调蛋白质信号通路和基因调控网络的下游变化。在这篇综述中，我们重点介绍了在生物电控制方面带来新见解的实验和分析，特别是作为复杂模式形成和组织再生的关键调节器。我们还讨论了利用这一基本的生物学现象在再生医学应用中开发新的治疗方法的机会。
Cell-to-cell communication is a cornerstone of multicellular existence. The ancient mechanism of sharing information between cells using the conductance of ions across cell membranes and the propagation of electrical signals through tissue space is a powerful means of efficiently controlling cell decisions and behaviors. Our understanding of how cells use changes in ‘bioelectrical’ signals to elicit systems-level responses has dramatically improved in recent years. We are now in a position to not just describe these changes, but to also predictively alter them to learn more about their importance for developmental biology and regenerative medicine. Recent work is helping researchers construct a more integrative view of how these simple controls can orchestrate downstream changes in protein signaling pathways and gene regulatory networks. In this review, we highlight experiments and analyses that have led to new insights in bioelectrical controls, specifically as key modulators of complex pattern formation and tissue regeneration. We also discuss opportunities for the development of new therapeutic approaches in regenerative medicine applications by exploiting this fundamental biological phenomenon.