Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.
Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.
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DOI：
10.1016/j.cld.2004.04.012
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发表时间：
2004-08-01
影响因子：
5.1
通讯作者：
Diehl, Anna Mae
中科院分区：
文献类型：
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作者：
Diehl, Anna Mae
非酒精性脂肪性肝病（NAFLD）是一种类似于酒精性脂肪性肝病（AFLD）的肝脏病理学谱，但在不酗酒的个体中发展。在人类中，NAFLD与肥胖、胰岛素抵抗和代谢异常综合征密切相关，但在这种临床背景下促进肝病的确切机制仍知之甚少。促炎性细胞因子FNF α是AFLD的关键介质。本文讨论了肿瘤坏死因子在胰岛素抵抗综合征（包括非酒精性脂肪综合征，包括非酒精性脂肪性肝病）发病机制中发挥作用的临床和实验证据。
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of hepatic pathology that resembles alcohol-induced fatty liver disease(AFLD), but which develops in individuals who are not heavy drinkers. In people, NAFLD is associated strongly with obesity,insulin resistance, and dysmetabolic syndrome, but the exact mechanisms that promote liver disease in this clinical context remain poorly understood. The proinflammatory cytokine, funor necrosis factor alpha is known to be a key mediator of AFLD. This article discusses clinical and experimental evidence that tumor necrosis factor plays a role in the pathogenesis of insulin resistance syndromes, including nonalcoholic fatty syndromes, including nonalcoholic fatty liver disease.