Relationship between concentration of serum leptin and fetal growth
Relationship between concentration of serum leptin and fetal growth
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DOI：
10.1210/jc.82.10.3281
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发表时间：
1997-10-01
影响因子：
5.8
通讯作者：
Morikawa, A
中科院分区：
文献类型：
--
作者：
Harigaya, A;Nagashima, K;Morikawa, A
血清瘦素浓度反映了体内脂肪组织的数量。虽然脂肪沉积在胎儿在妊娠晚期显着增加，瘦素在妊娠期间的作用还没有得到澄清。在本研究中，除了出生后最初几天瘦素水平如何变化之外，还研究了血清瘦素浓度是否与子宫内生长相关。将116名日本婴儿分为足月组（n = 91）和早产组（n = 25）。足月儿分为3个亚组：出生体重适合胎龄（阿加）（n = 44），出生体重大于胎龄（LGA）（n = 28），出生体重小于胎龄（SGA）（n = 19）。本文报告48例新生儿出生后血清瘦素水平的纵向变化。用放射免疫分析法测定28例新生儿脐血和出生后6 h内婴儿血清瘦素水平，结果显示脐血和新生儿血清瘦素水平无显著性差异。出生后6 h内，LGA组（12.8 ± 10.2 ng/mL）和SGA组（1.6 ± 1.1 ng/mL）的血清瘦素浓度分别显著高于和低于阿加组（4.4 ± 3.0 ng/mL）（P < 0.01）。生后6 h内瘦素水平与出生体重呈显著正相关（r = 0.59，P < 0.01）。LGA和阿加儿出生后48 h内血清瘦素水平明显低于SGA儿（P < 0.05）。出生后48 h，各组间瘦素水平无显著性差异，且低水平一直持续到7日龄，表明血清瘦素水平与胎儿体重增加有关。
The serum leptin concentration reflects the amount of adipose tissue in the body. Although fat deposition in the fetus in the third trimester markedly increases, the role of leptin during pregnancy has not been clarified. In the present study, whether or not the serum leptin concentration correlates with growth in utero was investigated, in addition to how leptin levels change in the first few days after birth. One hundred sixteen Japanese infants were divided into term (n = 91) and preterm groups (n = 25). Term infants were divided into 3 subgroups: birth weight appropriate for gestational age (AGA) (n = 44), birth weight large for gestational age (LGA) (n = 28), and birth weight small for gestational age (SGA) (n = 19). Longitudinal changes in the concentration of serum leptin after birth were examined in 48 infants. The serum leptin concentration was determined by RIA.No significant difference in leptin levels between cord sera and infants' sera obtained within the first 6 h of life (n = 28) was observed. Within the first 6 h of life, the concentration of serum leptin in LGA infants (12.8 +/- 10.2 ng/mL) and SGA infants (1.6 +/- 1.1 ng/mL) was significantly higher and lower, respectively, than that in the AGA infants (4.4 +/- 3.0 ng/mL) (P < 0.01). A significant positive correlation was found between the leptin concentration within 6 h of life and birth body weight (r = 0.59, P < 0.01). After birth, the concentration of leptin in LGA and AGA infants significantly decreased to the level in SGA infants within 48 h of delivery (P < 0.05). After 48 h of life, no significant differences in the concentration of leptin were observed among the three groups, and low levels continued to 7 days of age.These findings indicate that serum level of leptin correlates with fetal body weight gain.