MORPHOLOGY OF PEPTIDE-IMMUNOREACTIVE NEURONS IN THE RAT CENTRAL NUCLEUS OF THE AMYGDALA
MORPHOLOGY OF PEPTIDE-IMMUNOREACTIVE NEURONS IN THE RAT CENTRAL NUCLEUS OF THE AMYGDALA
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DOI：
10.1002/cne.902810212
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发表时间：
1989-03-08
影响因子：
2.5
通讯作者：
GRAY, TS
中科院分区：
文献类型：
--
作者：
CASSELL, MD;GRAY, TS
本文观察了大鼠杏仁中央核内肽免疫反应神经元的形态学特征。将观察结果与高尔基体染色组织的神经元形态学细节进行比较，以确定肽免疫反应性是否与中央核中的特定细胞类型相关。中央核的外侧亚部（CL）主要含有中等大小的，密集的棘状神经元。CL中也存在较大的、类棘状的神经元、中等大小的、稀疏的棘状神经元和小的棘状细胞。生长抑素，神经降压素，促肾上腺皮质激素释放因子（CRF），脑啡肽免疫反应神经元的CL的特点是中型多刺和较大的，棘状类型。含有不同肽的中型多刺神经元之间没有明显的形态学差异。在内侧亚部，P物质，神经降压素，生长抑素和CRF内存在于棘状，稀疏的棘状神经元长树突。甘丙肽的免疫反应在内侧亚部与中度多刺，cummiform神经元和一个较大的，棘，多边形神经元。中央核的腹侧亚部含有与相邻的内侧和外侧亚部中发现的神经元相似的神经元。此外，这个细分包含一个特征性的卵圆形神经元长，稀疏棘树突。血管活性肠多肽（VIP）和神经降压素似乎是本内这种细胞类型。在外侧囊亚部，神经降压素和脑啡肽存在于类似于中央核这一部分特征的中等多刺神经元的细胞中。梭形，双极生长抑素和VIP神经元的数量被确定在内侧，外侧和腹侧分区。本研究结果提供了证据的肽免疫反应神经元分布在大鼠中央核的细胞结构边界的异质形态。除P物质外，中央核的神经肽似乎由各种神经元表达，而不是由形态学特征类型的细胞表达。
The morphological characteristics of peptide-immunoreactive neurons in the rat central nucleus of the amygdala were examined. Observations were compared with details of neuron morphology available from Golgi-stained tissue to determine whether peptide immunoreactivity was associated with specific cell types in the central nucleus. The lateral subdivision (CL) of the central nucleus contained mainly medium-sized, densely spiny neurons. Larger, pyramiform spiny neurons; medium-sized, sparsely spinous neurons; and small, aspinous cells were also present in CL. Somatostatin-, neurotensin-, corticotropin-releasing factor (CRF)-, and enkephalin-immunoreactive neurons in CL were characterized as the medium spiny and larger, pyramiform types. No obvious morphological differences were evident among medium spiny neurons containing different peptides. In the medial subdivision, substance P, neurotensin, somatostatin, and CRF were present within pyramiform, sparsely spinous neurons with long dendrities. Galanin immunoreactivity in the medial subdivision was associated with moderately spiny, pyramiform neurons and a larger, aspinous, polygonal neuron. The ventral subdivision of the central nucleus contained neurons similar to those found in the adjacent medial and lateral subdivisions. In addition, this subdivision contained a characteristic ovoid neuron with long, sparsely spinous dendrities. Vasoactive intestinal polypeptide (VIP) and neurotensin appeared to be present within this cell type. In the lateral capsular subdivision, neurotensin and enkephalin were present in cells resembling the medium spiny neurons characteristic of this part of the central nucleus. Numbers of spindle-shaped, bipolar somatostatin, and VIP neurons were identified in the medial, lateral, and ventral subdivisions. The present results provide evidence for a heterogeneous morphology of peptide-immunoreactive neurons in the rat central nucleus that are distributed across cytoarchitectonic boundaries. Except for substance P, neuropeptides in the central nucleus appear to be expressed by a variety of neurons rather than morphologically characteristic types of cell.