Hyposmia in Progressive Supranuclear Palsy
Hyposmia in Progressive Supranuclear Palsy
复制标题
DOI：
10.1002/mds.22688
复制
发表时间：
2010-04-15
影响因子：
8.6
通讯作者：
Lees, Andrew J.
中科院分区：
文献类型：
--
作者：
Silveira-Moriyama, Laura;Hughes, Graham;Lees, Andrew J.
以往的研究表明，嗅觉是正常的进行性核上性麻痹（PSP）。我们应用宾夕法尼亚大学神经元识别测试（UPSIT）对36例PSP患者，他们在简易精神状态检查（MMSE）中得分超过18分，140例非痴呆帕金森病（PD）患者和126例对照组。调整年龄、性别和吸烟史后，PSP组的平均UPSIT评分低于对照组（P <0.001），但高于PD组（P < 0.001）。对于PSP患者。UPSIT评分与MMSE相关（r = 0.44，P = 0.006），但与疾病持续时间（P = 0.6）、统一帕金森病评定量表的运动子量表（P = 0.2）或正面评估组合（P = 0.5）无关。对6名PSP患者的大脑进行了尸检，所有人都发现了中脑的神经元缠结和tau蛋白积聚，尽管只有3名患者出现嗅觉减退。进一步的前瞻性研究，包括早期PSP和PSP-P与尸检确认的患者可能有助于澄清，如果嗅觉测试可能是有用的，当PD和PSP之间的鉴别诊断。(C)2010年运动障碍协会
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP. UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. (C) 2010 Movement Disorder Society