A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4
A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4
复制标题
DOI：
10.1371/journal.pone.0179963
复制
发表时间：
2017-06-26
期刊：
影响因子：
3.7
通讯作者：
Lee, Chien-Hsing
中科院分区：
文献类型：
--
作者：
Chien, Chu-Yen;Hung, Yi-Jen;Lee, Chien-Hsing
背景与目的蛋白质二硫键异构酶（PDI）家族成员是内质网中的特异性蛋白质，参与神经退行性疾病、癌症和肥胖等多种疾病的发病机制。然而，PDIA 4在人体中的代谢作用仍不清楚。本研究的目的是探讨中国成年人血清PDIA 4与代谢综合征（MetS）及其组分的关系。记录血清PDIA4浓度和生化变量。通过稳态模型评估检查胰岛素敏感性和β细胞功能。MetS的定义是基于修改后的国家胆固醇教育计划成人治疗小组III亚太地区标准。结果MetS参与者血清PDIA 4水平显著高于无MetS者（P
Background/ObjectivesProtein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study were to investigate the associations of serum PDIA4 with the metabolic syndrome (MetS) and its components in Chinese adults.Subjects/MethodsA total of 669 adults (399 men and 270 women) were recruited. Serum PDIA4 concentrations and biochemical variables were recorded. Insulin sensitivity and beta-cell function were examined by homeostasis model assessment. MetS was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asia Pacific.ResultsThe participants with MetS had significantly higher serum PDIA4 levels than those without MetS (P