Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Tannin
Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Tannin
复制标题
饲喂单宁的大鼠大脑体内抗氧化能力的增强
DOI：
10.1007/s11064-013-1031-2
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发表时间：
2013
影响因子：
4.4
通讯作者：
T. Ikenoue
中科院分区：
文献类型：
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作者：
A. Nakajima;Y. Ueda;Emiko Matsuda;H. Sameshima;T. Ikenoue
观察了口服含羞草单宁（MMT）对大鼠海马内抗氧化能力的影响。用含有0.1g/kg MMT的啮齿动物饲料（RD）（RD-MMT）饲养6周龄的Wistar大鼠8周。用微透析-电子自旋共振系统测定自由运动状态下可透过血脑屏障的稳定氮氧自由基3-甲氧羰基-2，2，5，5-四甲基吡咯烷-1-氧自由基（PCAM）的衰减，评价大鼠脑的抗氧化能力。RD-MMT组大鼠脑内PCAM的衰减速率明显大于对照组，说明RD-MMT组大鼠脑内抗氧化能力增强。体外实验表明，MMT对PCAM无直接还原作用，但对抗坏血酸对PCAM的还原有促进作用。这些结果表明，MMT是一种有效的抗氧化剂在体外和体内。
The effect of the oral administration of mimosa tannin (MMT) on the rat intra-hippocampal antioxidant ability was examined. Wistar rats at the age of 6 weeks were reared for 8 weeks with the rodent diet (RD) consisting of 0.1 g/kg of MMT (RD–MMT). The antioxidant ability of rat brain was evaluated from the decay of a brain–blood-barrier permeable stable nitroxide, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM) measured by the microdialysis-electron spin resonance system under a freely moving state. The decay rate of PCAM in the brain of rats fed RD–MMT was significantly larger than that of rats fed control rodent diet, which indicates the increase of the antioxidant ability in the brain of rats fed RD–MMT. In vitro study showed that MMT did not reduce PCAM directly but enhanced the reduction of PCAM by ascorbic acid. These results indicate that MMT is a potent antioxidant in vitro and in vivo.
左乙拉西坦的神经保护作用源自对大鼠海马内源性抗氧化剂的协同作用。
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
Ueda;Y.;Takaki;M.;Doi;T.;Nagatomo;K.;Nakajima;A.;Willmore;J
通讯作者：
J
影响因子：
1.6
作者：
A. Nakajima;Emiko Matsuda;Y. Ueda
通讯作者：
A. Nakajima;Emiko Matsuda;Y. Ueda