Prolongation of murine thyroid allografts by interleukin 2 (DAB486)-toxin and RS-61443.
Prolongation of murine thyroid allografts by interleukin 2 (DAB486)-toxin and RS-61443.
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白细胞介素 2 (DAB486) 毒素和 RS-61443 延长小鼠甲状腺同种异体移植物。
DOI：
10.1007/978-3-642-77423-2_143
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Sollinger,HW
中科院分区：
文献类型：
--
作者：
Hullett,DA;Landry,AS;Eckoff,DE;Nichols,JC;Eugui,EM;Allison,AC;Sollinger,HW
We evaluated the efficacy of interleukin 2 (DAB486)-toxin (IL-2-diphtheria toxin fusion protein; IL-2-toxin) in combination with RS-61443 to prolong murine thyroid allograft survival. B10.BR thyroid allografts were transplanted beneath the renal subcapsule in recipient (C57BL/10 mice and graft survival determined 21 days later. Treatment with IL-2-toxin (25 µg/day for 14 days) was unable to prolong graft survival significantly. RS-61443 treatment (21 days) achieved significant graft prolongation only at doses of 300 mg/kg daily or greater. When both drugs were used in combination (IL-2-toxin, 25µg/day for 14 days RS-61443 200 mg/kg daily for 21 days), statistically significant (P< 0.0001) graft prolongation was obtained. Our results suggest that IL-2-toxin in combination with subtherapeutic RS-61443 levels significantly prolongs murine thyroid allograft survival. IL-2-toxin and RS-61443, because of their unique and complementary mechanisms, hold promise for more selective immunosuppression.
