A concise total synthesis of naamidine A

A concise total synthesis of naamidine A
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DOI:
10.1021/ol052568o
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发表时间:
2006-02-02
期刊:
影响因子:
5.2
通讯作者:
Watson, KG
Watson, KG
中科院分区:
化学1区
文献类型:
--
作者:
Aberle, NS;Lessene, G;Watson, KG

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A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate alpha-aminoketone with cyanamide.