3D-printed silicate porous bioceramics using a non-sacrificial preceramic polymer binder
3D-printed silicate porous bioceramics using a non-sacrificial preceramic polymer binder
复制标题
DOI：
10.1088/1758-5090/7/2/025008
复制
发表时间：
2015-05
期刊：
影响因子：
9
通讯作者：
A. Zocca;H. Elsayed;E. Bernardo;C. Gomes;M. Lopez-Heredia;C. Knabe;P. Colombo;J. Günster
中科院分区：
文献类型：
--
作者：
A. Zocca;H. Elsayed;E. Bernardo;C. Gomes;M. Lopez-Heredia;C. Knabe;P. Colombo;J. Günster
硅酸盐生物陶瓷具有优异的生物活性，然而，将其成形为复杂的几何形状仍然具有挑战性。因此，本文的目的是提出一种新的策略，从玻璃粉末结合陶瓷前体聚合物，即硅树脂，和反应性填料的形状与控制的几何形状和性能的玻璃陶瓷。在这项工作中，基于粉末的三维（3D）打印的硅灰石（CaSiO 3）基硅酸盐生物陶瓷部件被证明。该树脂具有双重作用，因为它不仅在印刷过程中作为填料粉末的非牺牲性粘合剂，而且还与填料反应以产生所需的生物陶瓷相。在3D打印光盘中评估了机械和物理性能，即球对三球测试，密度，孔隙率和形态。这些样品具有约64体积%的总孔隙率和约6 MPa的双轴弯曲强度。这项工作中使用的原材料还能够3D打印具有设计的多尺度孔隙率，合适的生物陶瓷相组合和1 MPa的抗压强度的支架（对于总孔隙率≥ 80体积%的圆柱形支架）。还进行了在TRIS/HCl中的溶解度和体外测定，即活力、细胞毒性和凋亡测定。体外试验表明，细胞活力良好，对细胞无细胞毒性作用。
Silicate bioceramics possess an excellent bioactivity; however, shaping them into complex geometries is still challenging. Therefore, this paper aims to present a new strategy for the shaping of a bioglass-ceramic with controlled geometry and properties starting from a glass powder combined with a preceramic polymer, i.e. a silicon resin, and reactive fillers. The powder-based three-dimensional (3D)-printing of wollastonite (CaSiO3)-based silicate bioceramic parts was demonstrated in this work. The resin plays a dual role, as it not only acts as a non-sacrificial binder for the filler powders in the printing process but it also reacts with the fillers to generate the desired bioceramic phases. The mechanical and physical properties, i.e. ball-on-three-balls test, density, porosity and morphology, were evaluated in 3D-printed discs. These samples possessed a total porosity around 64 vol% and a biaxial flexural strength around 6 MPa. The raw materials used in this work also enabled the 3D-printing of scaffolds possessing a designed multi-scale porosity, suitable bioceramic phase assemblage and a compressive strength of 1 MPa (for cylindrical scaffolds with total porosity ∼80 vol%). Solubility in TRIS/HCl and in vitro assays, i.e. viability, cytotoxicity and apoptosis assays, were also performed. In vitro tests indicated good cell viability and no cytotoxicity effect on the cells.