A genome scan for Loci associated with aerobic running capacity in rats.
A genome scan for Loci associated with aerobic running capacity in rats.
复制标题
DOI：
10.1006/geno.2002.6797
复制
发表时间：
2002-07
期刊：
影响因子：
4.4
通讯作者：
J. A. Ways;G. Cicila;M. Garrett;L. Koch
中科院分区：
文献类型：
--
作者：
J. A. Ways;G. Cicila;M. Garrett;L. Koch
有氧能力是一个复杂的性状，它定义了在能量传递中使用大气氧作为电子受体的效率。哥本哈根（COP）和DA近交系大鼠品系在有氧跑步机跑步测试中显示出很大的差异，并作为有氧能力的对比遗传模型。对F（2）（COP × DA）分离群体（n=224）进行基因组扫描，检测与有氧跑能力相关的数量性状位点（QTL）。连锁分析表明，一个显着的QTL 16号染色体（lod评分，4.0）。在3号染色体的p-末端附近发现了一个暗示性的连锁（lod得分，2.2），并有证据表明与16号染色体上的另一个QTL相互作用（lod得分，2.9）。所有这三个QTL都表现出显性遗传模式，其中至少一个DA等位基因的存在与更大的距离运行。这些结果代表了在遗传模型中鉴定的第一个有氧能力QTL。
Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity. A genome scan was carried out on an F(2)(COP x DA) segregating population (n=224) to detect quantitative trait loci (QTLs) associated with aerobic running capacity. Linkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0). A suggestive linkage was found near the p-terminus of chromosome 3 (lod score, 2.2) with evidence of an interaction with another QTL on chromosome 16 (lod score, 2.9). All three QTLs showed a dominant mode of inheritance in which the presence of at least one DA allele was associated with a greater distance run. These results represent the first aerobic capacity QTLs identified in genetic models.