NEUROBIOLOGY OF SEIZURE DISPOSITION - THE GENETICALLY EPILEPSY-PRONE RAT .7. NEUROANATOMICAL LOCALIZATION OF STRUCTURES RESPONSIBLE FOR SEIZURES IN THE GEPR - LESION STUDIES
NEUROBIOLOGY OF SEIZURE DISPOSITION - THE GENETICALLY EPILEPSY-PRONE RAT .7. NEUROANATOMICAL LOCALIZATION OF STRUCTURES RESPONSIBLE FOR SEIZURES IN THE GEPR - LESION STUDIES
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DOI：
10.1016/0024-3205(86)90367-x
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发表时间：
1986-09-08
期刊：
影响因子：
6.1
通讯作者：
BROWNING, RA
中科院分区：
文献类型：
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作者：
BROWNING, RA
鉴定的神经基板subserving听源性惊厥的GEPR是一项重要的任务，虽然它还没有完成，许多实验室采用各种技术作出了重要贡献，我们目前的理解。本综述着重于使用病变，以确定听源性惊厥的神经基板。脑干核团的病变似乎比前脑病变具有更大的减弱听源性惊厥的能力。事实上，一些前脑病变（背侧海马、尾状核、丘脑板内核）似乎会增强听源性癫痫发作的严重程度。另一方面，下丘（IC）的双侧病变已被证明可以完全消除听源性惊厥，而脑桥网状结构（PRF核）的病变可以消除除跑步发作外的所有方面，这表明这两个脑干结构是参与听源性惊厥表达的重要神经基质。大的双侧黑质病变似乎也减弱听源性惊厥。病变对听源性惊厥的影响与其对其他全身性癫痫发作模型的影响基本相似，数据似乎支持以下假设：所有全身性惊厥的表达都涉及两个解剖系统：（1）负责面部表情的前脑系统和前肢阵挛;（2）负责表达奔跑-弹跳阵挛和紧张的脑干系统。
Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural substrates of audiogenic convulsions. Lesions in brain stem nuclei appear to have a much greater ability to attenuate audiogenic convulsions than do forebrain lesions. In fact, some forebrain lesions (dorsal hippocampus, caudate, intralaminar thalamic nuclei) appear to enhance the severity of audiogenic seizures. On the other hand, bilateral lesions in the inferior colliculus (IC) have been shown to completely abolish audiogenic convulsions, while lesions in the pontine reticular formation (PRF nucleus) abolish all aspects except the running episode suggesting that these two brain stem structures are important neural substrates involved in the expression of audiogenic convulsions. Large bilateral lesions of the substantia nigra also appear to attenuate audiogenic convulsions. The effect of lesions on audiogenic convulsions is basically similar to their effect on other generalized seizure models and the data appear to support the hypothesis that there are two anatomical systems involved in the expression of all generalized convulsions:(1) a forebrain system responsible for the expression of face and forelimb clonus; and (2) a brain stem system responsible in the expression of running-bouncing clonus and tonus.