Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
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DOI：
10.1016/s0896-6273(00)80371-2
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发表时间：
1997-09-01
期刊：
影响因子：
16.2
通讯作者：
TessierLavigne, M
中科院分区：
文献类型：
--
作者：
Chen, H;Chedotal, A;TessierLavigne, M
脑信号蛋白是一个分泌性跨膜蛋白家族，其中几种与排斥性轴突导向有关。神经纤毛蛋白（neuropilin-1）最近被鉴定为Collapsin-1/Semaphorin III/D（Sema III）的受体。我们报告的相关蛋白质，neuropilin-2，其mRNA的表达由发育中的神经元在很大程度上，虽然不是完全，nonoverlapping与neuropilin-1的模式。与以高亲和力结合三种结构相关的脑信号蛋白Sema III、Sema E和Sema IV的神经纤毛蛋白-1不同，神经纤毛蛋白-2仅显示出与Sema E和Sema IV的高亲和力结合，而不与Sema III结合。这些结果将神经纤毛蛋白鉴定为至少一个脑信号蛋白亚家族的受体家族（或受体组分）。他们还建议，该亚家族的不同成员的行动的特异性可能是由响应细胞表达的神经纤毛蛋白的补充。
Semaphorins are a targe family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III). We report the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neurons in a pattern largely, though not comptetely, nonoverlapping with that of neuropilin-1. Unlike neuropilin-1, which binds with high affinity to the th ree structurally related semaphorins Sema III, Sema E, and Sema IV, neuropilin-2 shows high affinity binding only to Sema E and Sema IV, not Sema III. These results identify neuropilins as a family of receptors (or components of receptors) for at least one semaphorin subfamily. They also suggest that the specificity of action of different members of this subfamily may be determined by the complement of neuropilins expressed by responsive cells.