Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma.
Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma.
复制标题
胸苷磷酸化酶/血小板衍生的内皮细胞生长因子表达与胃癌中的肝转移相关。
DOI：
10.1038/bjc.1996.177
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发表时间：
1996-04
影响因子：
8.8
通讯作者：
Sowa, M
中科院分区：
文献类型：
--
作者：
Maeda, K;Chung, Y S;Ogawa, Y;Takatsuka, S;Kang, S M;Ogawa, M;Sawada, T;Onoda, N;Kato, Y;Sowa, M
已知血管生成在实体瘤的生长和转移中起重要作用。已经鉴定了几种血管生成因子，并且血小板衍生的内皮细胞生长因子（PD-ECGF）被认为是这样的因子之一。最近，有报道胸苷磷酸化酶（dThdlase）与PD-ECGF相同。采用免疫组化方法检测120例胃癌组织中dThdR表达与微血管密度的关系。通过对因子VIII相关抗原的免疫染色确定的微血管密度，在dThdPase-positive肿瘤中显著高于dThdPase-negative肿瘤。dThdR表达与微血管密度增加显著相关。此外，在远处器官转移方面，dThdPase阳性肿瘤患者的肝转移频率显著高于dThdPase阴性肿瘤患者（P < 0.01）。综上所述，dThdPase表达与促进胃癌血管生成和肝转移密切相关。
It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF) is thought to be one such factor. Recently, it was reported that thymidine phosphorylase (dThdPase) is identical to PD-ECGF. Using immunohistochemical staining with an anti-dThdPase antibody, we investigated the correlation between dThdPase expression and the microvessel density in 120 gastric carcinomas. The microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in dThdPase-positive tumours than in dThdPase-negative tumors. There was a significant correlation between dThdPase expression and the increment of microvessel density. Moreover, regarding distant organ metastasis, the frequency of hepatic metastasis was significantly higher (P < 0.01) in patients with dThdPase-positive tumours than in those with dThdPase-negative tumors. In summary, it was suggested that dThdPase expression is closely associated with the promotion of angiogenesis and hepatic metastasis in gastric carcinoma.