Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits
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多模态功能分析平台：4.光遗传学诱导的振荡激活探索神经回路
DOI：
10.1007/978-981-15-8763-4_34
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Osanai Makoto
中科院分区：
文献类型：
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作者：
Mushiake Hajime;Ohshiro Tomokazu;Osawa Shin-ichiro;Hosaka Ryosuke;Katayama Norihiro;Tanaka Tetsu;Yawo Hiromu;Osanai Makoto
为了阐明脑功能振荡现象背后的神经机制，我们开发了光遗传学工具和统计方法。具体地说，光电流箝位诱导的振荡通过振荡共振揭示了神经回路固有的频率偏好。此外，共振或夹带到固有频率是状态相关的。当共振现象超过一定范围时，甚至可诱发癫痫发作，重现性强。我们能够研究癫痫是如何在神经回路中开始、发展和停止的。因此，光遗传学诱导的振荡激活是神经科学研究的有力工具
To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research