INCREASED PLASMA-CONCENTRATIONS OF INTERLEUKIN-6, SOLUBLE INTERLEUKIN-6, SOLUBLE INTERLEUKIN-2 AND TRANSFERRIN RECEPTOR IN MAJOR DEPRESSION
INCREASED PLASMA-CONCENTRATIONS OF INTERLEUKIN-6, SOLUBLE INTERLEUKIN-6, SOLUBLE INTERLEUKIN-2 AND TRANSFERRIN RECEPTOR IN MAJOR DEPRESSION
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DOI：
10.1016/0165-0327(95)00028-l
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发表时间：
1995-08-18
影响因子：
6.6
通讯作者：
DESNYDER, R
中科院分区：
文献类型：
--
作者：
MAES, M;MELTZER, HY;DESNYDER, R
近年来研究发现，抑郁症可能伴随着细胞免疫和体液免疫的显著变化。本研究旨在探讨抑郁症患者急性期、缓解期和抗抑郁治疗期间血浆白细胞介素（IL）-6、可溶性IL-6受体（sIL-6 R）、sIL-2 R和转铁蛋白受体（TfR）的水平。抑郁症患者血浆IL-6、sIL-6 R、sIL-2 R和TfR水平显著高于健康对照组。抑郁症患者血浆IL-6与sIL-6 R、IL-6与sIL-2 R、IL-6与TfR、sIL-2 R与TfR均呈显著正相关，而正常对照组无显著相关。抗抑郁药（如氟西汀或三环类抗抑郁药）亚慢性治疗对血浆IL-6、sIL-6 R、sIL-2 R或TfR无显著影响。后者在急性期或完全临床缓解期的抑郁症患者之间没有显着差异。建议：（1）IL-6、sIL-6 R、sIL-2 R和TfR的协同和上调的产生可能构成重性抑郁症的特征标志;（2）IL-6的上调产生可能代表重性抑郁症中遇到的各种免疫障碍的促成因素，并且可能是该疾病的病理生理学或发病机制。
Recently, it was found that major depression may be accompanied by significant changes in cell-mediated and humoral immunity. The purpose of this study was to investigate the plasma concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), sIL-2R and transferrin receptor (TfR) in patients with major depression in an acute phase of illness, in remission and during antidepressive treatment. Plasma concentrations of IL-6, sIL-6R, sIL-2R and TfR were significantly higher in major depressed subjects than in healthy controls. In major depressed subjects, but not in normal controls, there were significant positive correlations between the plasma concentrations of IL-6 and sIL-6R, IL-6 and sIL-2R, IL-6 and TfR, and between sIL-2R and TfR. Subchronic treatment with antidepressive drugs, such as fluoxetine or tricyclic antidepressants, did not significantly affect plasma IL-6, sIL-6R, sIL-2R or TfR. The latter did not significantly differ between major depressed patients in an acute phase of illness or in complete clinical remission. It is suggested that: (1) a coordinated and upregulated production of IL-6, sIL-6R, sIL-2R and TfR may constitute a trait marker of major depression; and that (2) an upregulated production of IL-6 may represent a contributing factor to the various immune disorders encountered in major depression and maybe to the pathophysiology or pathogenesis of that illness.