Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis
Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis
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卵巢子宫内膜异位症女性卵巢子宫内膜异位病变中的神经纤维
DOI：
10.1093/humrep/dep427
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发表时间：
2010-02-01
影响因子：
6.1
通讯作者：
Zhou, Caiyun
中科院分区：
文献类型：
--
作者：
Zhang, Xinmei;Yao, Huijiao;Zhou, Caiyun
虽然神经纤维存在于异位和异位子宫内膜中，但它们是否出现在卵巢子宫内膜异位症病变中尚不清楚。我们研究了卵巢子宫内膜异位症病变中神经纤维的存在及其与卵巢子宫内膜异位症女性临床参数的相关性。采用特异的兔抗蛋白基因产物9.5 （PGP9.5）抗体对61例腹腔镜子宫内膜异位症（II-IV期）卵巢子宫内膜异位症病变的组织学切片进行免疫组织化学染色，以显示有髓鞘和无髓鞘神经纤维。31.1%的女性卵巢子宫内膜异位症病变中检测到PGP9.5染色的神经纤维，且多出现在卵巢子宫内膜异位症病变的纤维化间质中。有疼痛症状的女性卵巢子宫内膜异位症病变中pgp9.5免疫活性纤维的密度（n = 35）高于无疼痛症状的女性（n = 26, P = 0.039），尽管pgp9.5阳性纤维的百分比（阳性病例/总数）没有差异。在有疼痛症状的女性中，40.0%的病例出现pgp9.5阳性纤维，卵巢子宫内膜异位症病变中pgp9.5免疫活性纤维的密度与疼痛症状的严重程度相关（r = 0.466, P = 0.005）。在无疼痛的女性中，只有5名（19.2%）女性检测到pgp9.5阳性纤维。卵巢子宫内膜异位症病变中pgp9.5阳性纤维的百分比和密度与盆腔粘连相关(chi(2) = 6.833, P = 0.009；Z = 2.442, P = 0.015)，但与疾病严重程度无关。卵巢子宫内膜异位症病变中pgp9.5免疫活性神经纤维可能参与卵巢子宫内膜异位症患者疼痛产生和盆腔粘连形成的病理生理过程。
Although nerve fibres are present in eutopic and ectopic endometrium, it is unclear whether they appear in ovarian endometriotic lesions. We investigated the presence of nerve fibres in ovarian endometriotic lesions and its correlation with clinical parameters in women with ovarian endometriosis.Histological sections of ovarian endometriotic lesions from 61 women with ovarian endometriosis (Stages II-IV) who underwent laparoscopic endometrioma cystectomy were stained immunohistochemically using a specific polyclonal rabbit anti-protein gene product 9.5 (PGP9.5) antibody to demonstrate myelinated and unmyelinated nerve fibres.Nerve fibres stained with PGP9.5 were detected in ovarian endometriotic lesions in 31.1% of women, and most appeared in fibrotic interstitium of ovarian endometriotic lesions. The density of PGP9.5-immunoactive fibres in ovarian endometriotic lesions in women with pain symptoms (n = 35) was higher than in women with no pain symptoms (n = 26, P = 0.039), although the percentage (positive cases/total) of PGP9.5-positive fibres did not differ. In women with pain symptoms, PGP9.5-positive fibres appeared in 40.0% of cases and the density of PGP9.5-immunoactive fibres in ovarian endometriotic lesions was correlated with severity of pain symptoms (r = 0.466, P = 0.005). In women with no pain, PGP9.5-positive fibres were detected in only 5 (19.2%) women. Both the percentage and the density of PGP9.5-positive fibres in ovarian endometriotic lesions were associated with pelvic adhesions (chi(2) = 6.833, P = 0.009; Z = 2.442, P = 0.015, respectively) but not with disease severity.PGP9.5-immunoactive nerve fibres in ovarian endometriotic lesions may be involved in the pathophysiology of pain generation and pelvic adhesion formation in women with ovarian endometriosis.