The ties that bond: neurochemistry of attachment in voles.
The ties that bond: neurochemistry of attachment in voles.
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DOI：
10.1016/j.conb.2016.04.011
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发表时间：
2016-06
影响因子：
5.7
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Gobrogge K;Wang Z
在社会一夫一妻制的草原田鼠（Microtus ochrogaster），交配诱导三种主要类型的行为，即，合作伙伴的偏好，对同种陌生人的选择性攻击，和双亲照顾，使这种啮齿动物的理想模型系统，研究社会性和潜在的神经化学机制与一夫一妻制的交配策略。在这里，我们强调了与交配经验相关的神经化学受体分布的物种差异，从而导致稳定的配对键的建立。具体来说，我们说明了多巴胺的核编程的形成和维护的一夫一妻制债券的作用，并描述了下丘脑前叶加压素的选择性侵略的调节作用。最后，我们讨论了最近的分子工作在田鼠，并强调这种啮齿动物的重要性，为未来的研究在行为神经生物学领域。
In socially monogamous prairie voles (Microtus ochrogaster), mating induces three primary types of behavior; namely, partner preference, selective aggression toward conspecific strangers, and bi-parental care, making this rodent an ideal model system to study sociality and underlying neurochemical mechanisms associated with monogamous mating strategies. Here, we highlight species differences in neurochemical receptor distributions associated with mating experience leading to the establishment of stable pair-bonds. Specifically, we illustrate the role of nucleus accumbens dopamine in programming the formation and maintenance of monogamous bonds and describe the role of anterior hypothalamic vasopressin in the regulation of selective aggression. We conclude by discussing recent molecular work in voles and emphasize the importance of this rodent for future research in the behavioral neurobiology field.