THE TAIL SUSPENSION TEST - A NEW METHOD FOR SCREENING ANTIDEPRESSANTS IN MICE
THE TAIL SUSPENSION TEST - A NEW METHOD FOR SCREENING ANTIDEPRESSANTS IN MICE
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DOI：
10.1007/bf00428203
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发表时间：
1985-01-01
影响因子：
3.4
通讯作者：
SIMON, P
中科院分区：
文献类型：
--
作者：
STERU, L;CHERMAT, R;SIMON, P
设计了一种新的抗抑郁药测试程序，其中一只老鼠的尾巴悬挂在杠杆上，动物的运动被记录下来。试验的总持续时间（6 min）可分为搅拌和不动期。研究了几种精神药物：安非他明、阿米替林、阿托品、地昔帕明、米安色林、诺米芬辛和维洛沙嗪。抗抑郁药会缩短不动的持续时间，精神兴奋剂和阿托品也是如此。如果结合不同条件下的运动活动测量，该测试可以将运动刺激剂剂量与抗抑郁剂剂量分开。安定会延长不动的时间。该程序的主要优点是使用简单、客观的测试情况，结果与Porsolt的经验证的“行为绝望”测试一致，以及对广泛的药物剂量的敏感性。
A novel test procedure for antidepressants was designed in which a mouse is supended by the tail from a lever, the movements of the animal being recorded. The total duration of the test (6 min) can be divided into periods of agitation and immobility. Several psychotropic drugs were studied: amphetamine, amitriptyline, atropine, desipramine, mianserin, nomifensine and viloxazine. Antidepressant drugs decrease the duration of immobility, as do psychostimulants and atropine. If coupled with measurement of locomotor activity in different conditions, the test can separate the locomotor stimulant doses from antidepressant doses. Diazepam increases the duration of immobility. The main advantages of this procedure are the use of a simple, objective test situation, the concordance of the results with the validated "behavioral despair" test from Porsolt and the sensitivity to a wide range of drug doses.