Understanding ERM proteins - the awesome power of genetics finally brought to bear
Understanding ERM proteins - the awesome power of genetics finally brought to bear
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DOI：
10.1016/j.ceb.2006.12.004
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发表时间：
2007-02-01
影响因子：
7.5
通讯作者：
Fehon, Richard G.
中科院分区：
文献类型：
--
作者：
Hughes, Sarah C.;Fehon, Richard G.
在上皮细胞中，Ezrin、Radixin和Moesin（ERM）蛋白参与许多细胞功能，包括调节肌动蛋白细胞骨架、控制细胞形状、粘附和运动以及调节信号传导途径。然而，识别ERMs的特定细胞作用由于这些蛋白质之间的冗余而变得复杂。最近在模式生物中的遗传研究已经确定了ERM蛋白的独特作用。这些包括调节上皮细胞的形态发生和维持完整性、稳定细胞间连接和调节Rho小GT3。这些研究还表明，ERMs在肌动球蛋白收缩性和囊泡运输的上皮细胞的顶端域的作用。因此，遗传分析增强了我们对这些广泛表达的膜相关蛋白的理解。
In epithelial cells, the Ezrin, Radixin and Moesin (ERM) proteins are involved in many cellular functions, including regulation of actin cytoskeleton, control of cell shape, adhesion and motility, and modulation of signaling pathways. However, discerning the specific Cellular roles of ERMs has been complicated by redundancy between these proteins. Recent genetic studies in model organisms have identified unique roles for ERM proteins. These include the regulation of morphogenesis and maintenance of integrity of epithelial cells, stabilization of intercellular junctions, and regulation of the Rho small GTPase. These studies also suggest that ERMs have roles in actomyosin contractility and vesicular trafficking in the apical domain of epithelial cells. Thus, genetic analysis has enhanced our understanding of these widely expressed membrane-associated proteins.