Inhibition of respiration by a phorbol ester tumor promoter in murine cultured cells.
Inhibition of respiration by a phorbol ester tumor promoter in murine cultured cells.
复制标题
佛波酯肿瘤促进剂对小鼠培养细胞中呼吸的抑制。
DOI：
10.1016/0006-291x(82)91048-8
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
Weinstein,IB
中科院分区：
文献类型：
--
作者：
Backer,JM;Boersig,MR;Weinstein,IB
肿瘤促进剂12-O-十四酰基佛波醇-13-乙酸酯是正常和甲基胆蒽转化的C3 H 10 T1 2小鼠成纤维细胞中线粒体呼吸的有效抑制剂。在肿瘤促进剂浓度为10 - 8 M时，可以观察到这种抑制作用，在完整细胞暴露后几分钟内发生，而在生物学上无活性的类似物中则没有观察到。该作用似乎是通过抑制寡霉素敏感性ATP酶的功能来发挥的。因此，线粒体功能的改变可能与肿瘤促进过程有关。
The tumor promoter 12-O-tetradecanoyl phorbol-13-acetate is a potent inhibitor of mitochondrial respiration in both normal and methylcholanthrene-transformed C3H 10T1 2 mouse fibroblasts. This inhibition is seen at concentrations of tumor promoter in the range of 10− 8 M, occurs within a few minutes after exposure of the intact cells, and is not seen with a biologically inactive analog. The effect appears to be exerted through inhibition of the function of an oligomycin-sensitive ATPase. It is possible, therefore, that alterations in mitochondrial function are associated with the process of tumor promotion.