Antidepressant effects of acute sleep deprivation are reduced in highly controlled environments.
Antidepressant effects of acute sleep deprivation are reduced in highly controlled environments.
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在高度控制的环境中，急性睡眠剥夺的抗抑郁作用会降低。
DOI：
10.1016/j.jad.2023.07.116
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发表时间：
2023
影响因子：
6.6
通讯作者：
Gehrman,Philip
中科院分区：
文献类型：
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作者：
Goldschmied,JenniferR;Boland,Elaine;Palermo,Emma;Barilla,Holly;Dinges,DavidF;Detre,JohnA;Basner,Mathias;Sheline,YvetteI;Rao,Hengyi;Gehrman,Philip
背景最近的一项荟萃分析中总结的大量研究表明，睡眠剥夺会迅速改善大约 50% 的重度抑郁症 (MDD) 患者的抑郁症状，但这些研究通常是在临床环境中进行的。在这里，我们利用高度受控的实验方法研究了睡眠剥夺的影响。方法 36 名未服用抗抑郁药物的重度抑郁症患者和 10 名健康对照者 (HC) 完成了为期 5 天/4 夜的方案，包括适应、基线、完全睡眠剥夺 (TSD) 和恢复阶段。光线始终保持昏暗（≤50 lx），饮食受到控制，活动受到限制。在筛选时和实验之夜后的每天早上，使用改良的汉密尔顿抑郁量表（HRSD）评估当前情绪。结果研究日对两组的情绪都有显着影响。事后分析显示，MDD 组在 TSD 之前的研究开始后以及 HC 组在恢复睡眠后的情绪改善归因于 MDD 组的显着影响，但不是由于 TSD 期间 MDD 组的情绪改善。 TSD 36 小时内情绪没有进一步改善。局限性严格的资格要求可能会限制普遍性。不服药的要求可能偏向于抑郁程度较轻的样本。结论结果显示，患有中度重度抑郁症的个体在进入高度控制的实验室环境后，抑郁症状可以显着减轻。环境对情绪的影响可能很大，需要考虑。
BackgroundNumerous studies summarized in a recent meta-analysis have shown sleep deprivation rapidly improves depressive symptoms in approximately 50 % of individuals with major depressive disorder (MDD), however those studies were typically conducted in clinical settings. Here we investigated the effects of sleep deprivation utilizing a highly controlled experimental approach.Methods36 antidepressant-free individuals with MDD and 10 healthy controls (HC) completed a 5 day/4-night protocol consisting of adaptation, baseline, total sleep deprivation (TSD), and recovery phases. Light was kept consistently dim (≤50 lx), meals were regulated, and activity was restricted. In-the-moment mood was assessed using a modified Hamilton Rating Scale for Depression (HRSD) at screening and each morning following the experimental nights.ResultsDay of study had a significant effect on mood in both groups. Post-hoc analyses revealed that significant effects were attributed to mood improvement in the MDD group following study initiationprior tobeginning TSD, and in the HC group following recovery sleep, but were not due to mood improvement in the MDD group during TSD. No further improvement in mood occurred during 36 h of TSD.LimitationsStrict eligibility requirements may limit generalizability. The requirement to be medication free may have biased toward a less severely depressed sample.ConclusionsResults revealed that individuals with moderate MDD can experience a significant reduction in depressive symptoms upon entering a highly controlled laboratory environment. Environmental effects on mood can be substantial and need to be considered.