VisTCR: An Interactive Software for T Cell Repertoire Sequencing Data Analysis
VisTCR: An Interactive Software for T Cell Repertoire Sequencing Data Analysis
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DOI：
10.3389/fgene.2020.00771
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发表时间：
2020-07-21
影响因子：
3.7
通讯作者：
Wan, Ying
中科院分区：
文献类型：
--
作者：
Ni, Qingshan;Zhang, Jianyang;Wan, Ying
高通量测序技术的最新进展提供了探测T细胞受体（TCR）库的机会，带来了TCR测序数据和分析工具的爆炸式增长。为了更容易和更启发式的分析TCR测序数据，我们开发了一个基于客户端的HTML程序（VisTCR）。它有一个数据存储模块和一个数据分析模块，以分层的方式集成了多种尖端的分析算法。研究人员可以通过定制的“实验设计文件”对不同分析目的的样品进行分组和重新分组。此外，VisTCR提供了一个用户友好的交互界面，通过所有TCR分析方法和可视化结果可以在分析过程中访问和保存为表格或图形。源代码可以在https://github.com/qingshanni/VisTCR上免费获得。
Recent progress in high throughput sequencing technologies has provided an opportunity to probe T cell receptor (TCR) repertoire, bringing about an explosion of TCR sequencing data and analysis tools. For easier and more heuristic analysis TCR sequencing data, we developed a client-based HTML program (VisTCR). It has a data storage module and a data analysis module that integrate multiple cutting-edge analysis algorithms in a hierarchical fashion. Researchers can group and re-group samples for different analysis purposes by customized "Experiment Design File." Moreover, the VisTCR provides a user-friendly interactive interface, by all the TCR analysis methods and visualization results can be accessed and saved as tables or graphs in the process of analysis. The source code is freely available at https://github.com/qingshanni/VisTCR.