Reduction of food intake by intestinal macronutrient infusion is not reversed by NMDA receptor blockade.
Reduction of food intake by intestinal macronutrient infusion is not reversed by NMDA receptor blockade.
复制标题
NMDA 受体阻断不会逆转肠道常量营养素输注导致的食物摄入量减少。
DOI：
10.1152/ajpregu.2000.278.2.r345
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Burns,GA
中科院分区：
文献类型：
--
作者：
Covasa,M;Ritter,RC;Burns,GA
Rats increase their intake of food, but not water, after intraperitoneal injection of MK-801, a noncompetitive antagonist ofN-methyl-d-aspartate-activated ion channels. We hypothesized that MK-801 might enhance intake by interfering with intestinal chemosensory signals. To test this hypothesis, we examined the effect of the antagonist on 15% sucrose intake after an intraduodenal infusion of maltotriose, oleic acid, or phenylalanine in both real- and sham-feeding paradigms. MK-801 (100 μg/kg) significantly increased sucrose intake regardless of the composition of the infusate during real feeding. Furthermore, MK-801 had no effect on reduction of sucrose intake by intestinal nutrient infusions in sham-feeding rats. These results indicate that MK-801 does not increase meal size and duration by interfering with signals activated by intestinal macronutrients.
