Migration on a large scale
Migration on a large scale
复制标题
大规模迁移
DOI：
10.1038/ncb0804-683
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发表时间：
2004
影响因子：
21.3
通讯作者：
S. Étienne
中科院分区：
文献类型：
--
作者：
S. Étienne
无论是在正常情况下还是在病理条件下，细胞迁移都是发育和成年生物体的基本过程。自从20世纪70年代初Michael Abercrombie最初描述了培养细胞的迁移以来，这种复杂的细胞行为背后的分子机制的研究引起了人们的极大关注。在过去的十年中，对细胞运动性的全面分析取得了很大进展。遗传学、生物化学和细胞生物学技术的成功结合，尤其导致了对细胞骨架调控的许多关键因素的确定。由于细胞运动涉及到如此多不同的细胞和发育过程，从细胞骨架动力学的分子调控到细胞发育过程中细胞迁移的控制，很难在一本书中完成。然而，安妮·里德利、米歇尔·佩克汉姆和彼得·克拉克作为《细胞运动：从分子到有机体》的编辑接受了这一奇妙的挑战，这本书是献给迈克尔·阿伯克龙比的长期合作者琼·海斯曼的。参加第五届阿伯克龙比细胞运动研讨会(2003年9月在英国牛津举行)的50多名研究人员贡献了这本书，这本书由20章组成，每一章都可以独立阅读。总的来说，这些参考文献是非常及时的--对于一本涵盖这一快速发展的研究领域的书来说，这是一个重要的考虑因素。整本书本可以从包含细胞迁移原理的概述和更明确定义的章节组织的更详细的序言中获益；然而，每一章通常都提供了一个介绍，允许不熟悉该领域的读者将其置于细胞迁移的上下文中。
Cell migration is a fundamental process in the developing and adult organism—under both normal and pathological conditions. Since the original description of migrating cultured cells by Michael Abercrombie in the early 1970s, the study of the molecular mechanisms underlying this complex cellular behaviour has garnered considerable attention. During the last decade, a comprehensive analysis of cell motility has resulted in much progress. The successful combination of genetics, biochemical and cell biology techniques has, in particular, led to the identification of many key factors involved in regulating the cytoskeleton. Because cell motility is involved in so many different cellular and developmental processes, covering the spectrum of topics from molecular regulation of cytoskeleton dynamics to control of cell migration during development is difficult to accomplish in a single book. Undeterred, however, Anne Ridley, Michelle Peckham and Peter Clark have undertaken this fantastic challenge as the editors of Cell Motility: From Molecules to Organisms, which is dedicated to Joan Heaysman, a long-time collaborator of Michael Abercrombie.Contributed to by more than 50 researchers participating in the 5th Abercrombie Symposium on Cell Motility (held in Oxford, UK, September 2003), this book consists of 20 chapters each of which can be read independently of the others. The references are, on the whole, remarkably up to date—an important consideration for a book covering this rapidly evolving area of research. The entire book would have gained from a more detailed preface containing an overview of the principles of cell migration and a more clearly defined organization of the chapters; however, each chapter generally provides an introduction that will allow readers unfamiliar with this field to place it within the context of cell migration.