Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis.
Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis.
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DOI：
10.1248/bpb.25.1101
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发表时间：
2002-08
影响因子：
2
通讯作者：
I. Mook-Jung;H. Kim;W. Fan;Y. Tezuka;S. Kadota;H. Nishijo;M. Jung
中科院分区：
文献类型：
--
作者：
I. Mook-Jung;H. Kim;W. Fan;Y. Tezuka;S. Kadota;H. Nishijo;M. Jung
We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H2O2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.
