Effect of murine interferon gamma on murine toxoplasmosis.
Effect of murine interferon gamma on murine toxoplasmosis.
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鼠干扰素γ对鼠弓形虫病的作用。
DOI：
10.1093/infdis/150.6.961
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Remington,JS
中科院分区：
文献类型：
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作者：
McCabe,RE;Luft,BJ;Remington,JS
每隔一天注射5×103单位的小鼠干扰素-γ，直到对照组(未感染)小鼠开始死亡，可完全保护小鼠免受弓形虫病的死亡，而未治疗的感染小鼠有50%死亡。在第二个实验中，注射5×10~3、5×102或5×10个单位干扰素-γ的小鼠的存活时间显著延长。两次注射5×103或5×104单位的干扰素-γ也能延长小鼠的存活时间。经治疗的保护性小鼠，但未经治疗的非保护性小鼠对弓形虫的染色滴度显著高于未经治疗的感染小鼠。进一步的实验表明，干扰素-γ的作用也可能是通过其激活巨噬细胞的能力来实现的。
Five × 103units of murine interferon-gamma (IFN-γ), administered every other day until control (uninfected) mice began to die, completely protected mice against death from toxoplasmosis, whereas 50% of untreated infected mice died. In a 2nd experiment, a significantly prolonged survival was observed in mice that received injections of 5 × 103, 5 × 102or 5 × 10 units of IFN-γ. Two injections only of either 5 × 103or 5 × 104units of IFN-γ also resulted in prolonged survival. Treated protected mice, but not treated unprotected mice had significantly higher dye test titres toToxoplasma gondiithan did untreated infected mice. A further experiment demonstrated that the effect of IFN-γ may also be mediated through its ability to activate macrophages.