Growth hormone and prolactin release after injection of thyrotropin-releasing hormone in patients with depression.
Growth hormone and prolactin release after injection of thyrotropin-releasing hormone in patients with depression.
复制标题
抑郁症患者注射促甲状腺激素释放激素后生长激素和催乳素的释放。
DOI：
10.1210/jcem-40-3-501
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Imura
中科院分区：
文献类型：
--
作者：
K. Maeda;Y. Kato;S. Ohgo;Kazuo Chihara;Y. Yoshimoto;N. Yamaguchi;Seishiro Kuromaru;H. Imura
研究了抑郁症患者促甲状腺素释放激素（TRH）对生长激素（GH）、催乳素（PRL）和促甲状腺素（TSH）释放的影响。静脉注射合成TRH（500微克）导致13名精神抑郁症患者中的8名血浆GH显着升高（峰值：7.7-35.0ng/ml）。临床康复后，这些患者的血浆 GH 对 TRH 没有反应。 TRH 给药不会升高正常受试者的血浆 GH。与对照组相比，抑郁症患者的血浆 PRL 对 TRH 的反应显着增强（P 小于 0.05）。抑郁症患者的血浆 TSH 对 TRH 的反应显着减弱（P 小于 0.05）。这些结果表明抑郁症患者的下丘脑-垂体功能存在紊乱。
The effects of thyrotropin-releasing hormone (TRH) on the release of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH) were investigated in patients with depression. Intravenous injection of synthetic TRH (500 mug) caused a significant increase in plasma GH (peak value: 7.7 minus 35.0 ng/ml) in 8 of 13 patients with mental depression. After clinical recovery these patients had no response of plasma GH to TRH. TRH administration did not raise plasma GH in normal subjects examined. Plasma PRL responses to TRH were significantly enchanced (P smaller than 0.05) in depressed patients compared with control subjects. Plasma TSH responses to TRH were significantly blunted in patients with depression (P smaller than 0.05). These results suggest disorders in the hypothalamo-pituitary function in depression.