Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.
Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.
复制标题
生长抑素对囊肿性伴有寄生虫负担和颗粒状反应负调节。
DOI：
10.1155/2014/247182
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发表时间：
2014
影响因子：
--
通讯作者：
Robinson P
中科院分区：
文献类型：
--
作者：
Khumbatta M;Firozgary B;Tweardy DJ;Weinstock J;Firozgary G;Bhatena Z;Bulsara T;Siller R;Robinson P
Cysticercosis is an infection of tissues with the larval cysts of the cestode, Taenia solium. While live parasites elicit little or no inflammation, dying parasites initiate a granulomatous reaction presenting as painful muscle nodules or seizures when cysts are located in the brain. We previously showed in the T. crassiceps murine model of cysticercosis that substance P (SP), a neuropeptide, was detected in early granulomas and was responsible for promoting granuloma formation, while somatostatin (SOM), another neuropeptide and immunomodulatory hormone, was detected in late granulomas; SOM's contribution to granuloma formation was not examined. In the current studies, we used somatostatin knockout (SOM−/−) mice to examine the hypothesis that SOM downmodulates granulomatous inflammation in cysticercosis, thereby promoting parasite growth. Our results demonstrated that parasite burden was reduced 5.9-fold in SOM−/− mice compared to WT mice (P < 0.05). This reduction in parasite burden in SOM−/− mice was accompanied by a 95% increase in size of their granulomas (P < 0.05), which contained a 1.5-fold increase in levels of IFN-γ and a 26-fold decrease in levels of IL-1β (P < 0.05 for both) compared to granulomas from WT mice. Thus, SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-γ and IL-1β.
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影响因子：
3.1
作者：
Robinson, P;White, AC;Weinstock, J
通讯作者：
Weinstock, J
影响因子：
--
作者：
Garza, Armandina;Tweardy, David J.;Robinson, Prema
通讯作者：
Robinson, Prema
影响因子：
2.6
作者：
Zhang, Y.;Huang, W.;Xu, J.
通讯作者：
Xu, J.
影响因子：
4.4
作者：
Chowers, Y;Cahalon, L;Levite, M
通讯作者：
Levite, M
影响因子：
3.1
作者：
Halonen, SK;Chiu, FC;Weiss, LM
通讯作者：
Weiss, LM