LOCI DIFFERENTIALLY AFFECTED BY SELECTION IN 2 AMERICAN BLACK POPULATIONS
LOCI DIFFERENTIALLY AFFECTED BY SELECTION IN 2 AMERICAN BLACK POPULATIONS
复制标题
DOI：
10.1073/pnas.68.10.2554
复制
发表时间：
1971-01-01
影响因子：
11.1
通讯作者：
HESSER, JE
中科院分区：
文献类型：
--
作者：
BLUMBERG, BS;HESSER, JE
通过比较两个美国黑人群体来检验受选择影响的基因座差异的假设，该假设以前曾在格鲁吉亚州埃文斯县进行过研究，并将该研究的数据与从格鲁吉亚州萨佩洛岛获得的数据进行了比较，在这两个群体中，确定了21个多态系统的基因频率。通过使用公式：m=（qn-qAf）/（qw-qAf），对从白人到这些黑人群体的14个基因迁移特征（m）进行了估计，其中qw、qn和qAf分别是等位基因在白色、黑人和西非群体中的频率。在这个计算中，假设美国黑人和非洲人之间的基因频率差异完全是由于基因混合造成的。在此假设下，如果只有基因混合物在起作用，则为每个基因座确定的“m”值将大致相同。如果“m”在某些位点上的值与在其他位点上的值不同，那么对这些位点上分离基因控制的性状的选择可以解释这种差异。对每个群体的这些值进行排名，并比较排名顺序。两个群体的基因座排列顺序之间存在极显著的相关性。这一发现支持了这样的假设，即基因座差异影响的选择可以确定，选择力在两个群体中相同的基因座上操作。
The hypothesis that loci differentially affected by selection can be identified was tested by a comparison of two American black populations.The hypothesis had previously been studied in Evans County, Georgia and the data from that study were compared with data obtained from the population of Sapelo Island, Georgia.In both, gene frequencies for 21 polymorphic systems were determined. Estimates were made for 14 of these traits of the gene migration (m) from whites into these black populations, by use of the equation:m= (qn-qAf)/(qw-qAf), whereqw, qn, andqAfare the frequencies of an allele in the white, black, and West African populations, respectively. In this calculation, it is assumed that the differences in gene frequencies between American blacks and Africans are due entirely to gene mixture. On this assumption, if only gene mixture were operating, the values of “m” determined for each locus would be about the same. If “m” has a different value at some loci than it has at others, then selection for traits controlled by genes segregating at these loci could account for this difference.Values of “m” in both populations were scattered. These values were ranked for each population and the rank orders compared. There was a highly significant association between the rank order of loci in the two populations. This finding supports the hypothesis that loci differentially affected by selection can be identified, and that the selective forces have operated on the same loci in both populations.