Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics
Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics
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DOI：
10.1016/j.psyneuen.2012.09.018
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发表时间：
2013-06-01
影响因子：
3.7
通讯作者：
Neumann, Inga D.
中科院分区：
文献类型：
--
作者：
Lukas, Michael;Toth, Lulia;Neumann, Inga D.
脑催产素（OXT）在实验室啮齿动物的短期社会记忆中发挥着重要作用。在这里，我们监测了 OXT 的局部释放及其在社会歧视测试期间维持和检索社会记忆的功能参与。我们进一步评估了OXT在内侧杏仁核（MeA）和外侧隔膜（LS）内对社会辨别能力的局部影响是否依赖于社会刺激的生物学相关性，从而比较雄性青少年与成年雌性同种。在雄性青少年刺激的社会记忆检索过程中，但在获取或维持雄性青少年刺激的社会记忆过程中，雄性大鼠的LS中OXT释放增加，但在获取或维持过程中则没有增加。在获得社会记忆后立即通过脑室内（ICV）给予特定的OXT受体拮抗剂（OXTR-A，大鼠：0.75μg/5μl，小鼠：2μg/2μl）来阻断OXT活性，损害了社会记忆的维持，从而损害了社会记忆检索期间的辨别能力。相比之下，在两个物种恢复社会记忆之前 20 分钟施用 ICY OXTR-A 则没有效果。雄性小鼠的物体辨别测试中测量的非社交记忆不受 ICY OXTR-A 的影响，这表明大脑 OXT 主要是在社交环境中形成记忆所必需的。社交刺激的生物学相关性似乎重要地决定了社交记忆能力，因为雄性大鼠识别先前遇到的雌性成年刺激至少 2 小时（而雄性青少年需要 60 分钟），内源性 OXT 的贡献具有区域依赖性；而双侧给予MeA (0.1μg/1μl)的OXTR-A仅损害成年雌性的社会记忆，通过逆透析将OXTR-A给予LS(10μg/ml，1.0μl/min)会损害雄性青少年和成年女性的社会记忆。总体而言，这些结果表明，大脑 OXT 是雄性啮齿动物社会记忆的关键调解者，并且根据社会刺激的生物相关性，不同的大脑区域被招募来调解其影响。 (C) 2012 Elsevier Ltd. 保留所有权利。
Brain oxytocin (OXT) plays an important role in short-term social memory in laboratory rodents. Here we monitored local release of OXT and its functional involvement in the maintenance and retrieval of social memory during the social discrimination test. We further assessed, if the local effects of OXT within the medial amygdala (MeA) and lateral septum (LS) on social discrimination abilities were dependent on the biological relevance of the social stimulus, thus comparing male juvenile versus adult female conspecifics.OXT release was increased in the LS of male rats during the retrieval, but not during the acquisition or maintenance, of social memory for male juvenile stimuli. Blockade of OXT activity by intracerebroventricular (ICV) administration of a specific OXT receptor antagonist (OXTR-A, rats: 0.75 mu g/5 mu l, mice: 2 mu g/2 mu l) immediately after acquisition of social memory impaired the maintenance of social memory, and consequently discrimination abilities during retrieval of social memory. In contrast, ICY OXTR-A was without effect when administered 20 min prior to retrieval of social memory in both species. Non-social memory measured in the object discrimination test was not affected by ICY OXTR-A in male mice, indicating that brain OXT is mainly required for memory formation in a social context.The biological relevance of the social stimulus seems to importantly determine social memory abilities, as male rats recognized a previously encountered female adult stimulus for at least 2 h (versus 60 min for male juveniles), with a region-dependent contribution of endogenous OXT; while bilateral administration of OXTR-A into the MeA (0.1 mu g/1 mu l) impaired social memory for adult females only, administration of OXTR-A into the LS via retrodialysis (10 mu g/ml, 1.0 mu l/min) impaired social memory for both male juveniles and female adults. Overall, these results indicate that brain OXT is a critical mediator of social memory in male rodents and that, depending on the biological relevance of the social stimulus, distinct brain regions are recruited to mediate its effects. (C) 2012 Elsevier Ltd. All rights reserved.