Preeclampsia Is Associated With Persistent Postpartum Cardiovascular Impairment
Preeclampsia Is Associated With Persistent Postpartum Cardiovascular Impairment
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DOI：
10.1161/hypertensionaha.111.176537
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发表时间：
2011-10-01
期刊：
影响因子：
8.3
通讯作者：
Thilaganathan, Basky
中科院分区：
文献类型：
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作者：
Melchiorre, Karen;Sutherland, George Ross;Thilaganathan, Basky
先兆子痫与疾病急性期无症状的整体左心室功能和几何结构异常相关。已知这些亚临床心脏异常在非妊娠患者的心血管危险分层中具有重要意义。此外，流行病学研究还表明先兆子痫与以后生活中的心脏病发病率和死亡率之间的关系。本研究的目的是评估产后自然史和临床意义的无症状左心室损害已知发生急性先兆子痫。这是一项前瞻性纵向病例对照研究，包括64例先兆子痫患者和78例匹配对照。有3个时间点评估，妊娠和产后1年和2年。评估包括病史和家族史、血压曲线、超声心动图和12导联ECG。在产后1年时，与足月先兆子痫（14%）或匹配对照组（8%）相比，早产先兆子痫（56%）中无症状的左心室中重度功能障碍/肥大显著更高（P值
Preeclampsia is associated with asymptomatic global left ventricular abnormal function and geometry during the acute phase of the disorder. These subclinical abnormalities in cardiac findings are known to be important in cardiovascular risk stratification for nonpregnant patients. Furthermore, epidemiological studies have also demonstrated a relationship between preeclampsia and cardiac morbidity and mortality later in life. The aim of this study was to evaluate the postpartum natural history and clinical significance of asymptomatic left ventricular impairment known to occur with acute preeclampsia. This was a prospective longitudinal case-control study of 64 subjects with preeclampsia and 78 matched controls. There were 3 time point assessments, pregnancy and 1 and 2 years postpartum. The assessments included a medical and family history, blood pressure profile, echocardiography, and 12-lead ECG. At 1 year postpartum, asymptomatic left ventricular moderate-severe dysfunction/hypertrophy was significantly higher in preterm preeclampsia (56%) compared with term preeclampsia (14%) or matched controls (8%; P values