C-reactive protein and postmenopausal breast cancer risk: results from the E3N cohort study
C-reactive protein and postmenopausal breast cancer risk: results from the E3N cohort study
复制标题
DOI：
10.1007/s10552-014-0355-9
复制
发表时间：
2014-04-01
影响因子：
2.3
通讯作者：
Mesrine, Sylvie
中科院分区：
文献类型：
--
作者：
Dossus, Laure;Jimenez-Corona, Aida;Mesrine, Sylvie
C 反应蛋白 (CRP) 是一种低度炎症标志物，与乳腺癌风险相关，但结果很少且不一致。 E3N 前瞻性队列中的一项病例对照研究包括 549 例绝经后乳腺癌病例和 1,040 例匹配对照，所有基线时均未患乳腺癌。测量了 1995 年至 1999 年间收集的样本中的 CRP 血清水平。使用无条件逻辑回归模型评估 CRP 与乳腺癌风险之间的关联，并调整匹配因素和已知的乳腺癌风险因素。总体而言，未观察到 CRP 水平与乳腺癌风险之间存在关联。然而，CRP 水平和体重指数 (BMI) 之间存在显着的相互作用。超重和肥胖女性（BMI 千分之一日元 25 kg/m(2)）的乳腺癌风险显着增加（与 CRP < 1.5 mg/L 相比，CRP 千分之一日元 2.5 mg/L 的 OR 1.92，95 % CI 1.20-3.08，p（趋势）= 0.003，CRP 与 BMI 之间的 p（交互作用）= 0.03）。在腰围 (WC) 千分之 88 厘米（p（趋势）= 0.01，p（交互）= 0.06）和腰臀比（WHR）千分之 0.80（p（趋势）= 0.06，p（交互）= 0.35）的女性中也观察到了类似的结果。在体重指数、腰围或腰臀比正常的女性中，CRP 水平与乳腺癌风险无关。我们发现，CRP 水平与绝经后乳腺癌风险之间存在正相关，仅限于肥胖过多的女性。低度炎症、腹部肥胖和绝经后乳腺癌风险之间的关系值得进一步研究。
C-reactive protein (CRP), a marker of low-grade inflammation, has been associated with breast cancer risk, but results are scarce and inconsistent.A case-control study nested within the E3N prospective cohort included 549 postmenopausal breast cancer cases and 1,040 matched controls, all free of breast cancer at baseline. Serum levels of CRP were measured in samples collected between 1995 and 1999. Unconditional logistic regression models were used to evaluate the association between CRP and breast cancer risk, adjusting for matching factors and known breast cancer risk factors.No association was observed between CRP levels and breast cancer risk overall. However, a significant interaction was observed between CRP levels and body mass index (BMI). A statistically significant increase in breast cancer risk was observed in overweight and obese women (BMI a parts per thousand yen 25 kg/m(2)) (OR 1.92, 95 % CI 1.20-3.08 for CRP a parts per thousand yen 2.5 mg/L compared with CRP < 1.5 mg/l, p (trend) = 0.003, p (interaction) between CRP and BMI = 0.03). Similar results were observed in women with waist circumference (WC) a parts per thousand yen 88 cm (p (trend) = 0.01, p (interaction) = 0.06) and waist-to-hip ratio (WHR) a parts per thousand yen 0.80 (p (trend) = 0.06, p (interaction) = 0.35). CRP levels were not associated with breast cancer risk in women with normal BMI, WC, or WHR.We found a positive association between CRP levels and postmenopausal breast cancer risk restricted to women with excess adiposity. The suggested relationship between low-grade inflammation, abdominal adiposity, and postmenopausal breast cancer risk deserves further investigation.