Fish intake and risk of incident atrial fibrillation
Fish intake and risk of incident atrial fibrillation
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DOI：
10.1161/01.cir.0000138154.00779.a5
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发表时间：
2004-07-27
期刊：
影响因子：
37.8
通讯作者：
Siscovick, DS
中科院分区：
文献类型：
--
作者：
Mozaffarian, D;Psaty, BM;Siscovick, DS
心房颤动（AF）是临床上最常见的心律失常，在老年人中尤为常见。虽然鱼类摄入量的影响，包括潜在的抗心律失常作用，可能会有利地影响房颤的风险，鱼类摄入量和房颤发病率之间的关系还没有evaluated.Methods和Results-In一个前瞻性的，以人口为基础的队列4815成人大于或等于65岁，通常的饮食摄入量进行了评估，在基线在1989年和1990年。金枪鱼和其他烧烤或烘烤的鱼的消费与血浆磷脂长链n-3脂肪酸相关，而油炸鱼或鱼三明治（鱼汉堡）的消费则没有。根据出院记录和年度心电图前瞻性确定房颤发生率。在12年的随访中，诊断出980例偶发性房颤。在多变量分析中，金枪鱼或其他烧烤或烘焙鱼类的消费与AF的发病率呈负相关，每周摄入1至4次的风险降低28（HR = 0.72，95%CI = 0.58 ~ 0.91，P = 0.005），每周摄入≥ 5次的风险降低31%（HR = 0.69，95% CI = 0.52至0.91，P = 0.008），与
Background-Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated.Methods and Results-In a prospective, population-based cohort of 4815 adults greater than or equal toage 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches ( fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years' follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HR = 0.72, 95% CI = 0.58 to 0.91, P = 0.005), and 31% lower risk with intake greater than or equal to5 times per week (HR = 0.69, 95% CI = 0.52 to 0.91, P = 0.008), compared with