ACTION OF PEPTIDES ON ADRENAL MEDULLA RELEASE OF ADRENALINE BY BRADYKININ + ANGIOTENSIN
ACTION OF PEPTIDES ON ADRENAL MEDULLA RELEASE OF ADRENALINE BY BRADYKININ + ANGIOTENSIN
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DOI：
10.1113/jphysiol.1964.sp007364
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发表时间：
1964-01-01
影响因子：
5.5
通讯作者：
LEWIS, GP
中科院分区：
文献类型：
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作者：
FELDBERG, W;LEWIS, GP
当注射到中央残端的腹腔动脉的内脏猫，麻醉与氯醛糖，缓激肽和血管紧张素被发现是有效的释放髓质激素从肾上腺，证明了随之而来的收缩的失神经支配的瞬膜和血压的变化。缓激肽的阈值剂量在0.05和1 /IG之间变化;对于血管紧张素，有时检测到肾上腺素的释放只有1 - 2 ng。通过腹腔动脉注射时，缓激肽的释放量与其自身重量一样多，血管紧张素的释放量有时高达其自身重量的100倍，或者是儿茶酚胺，尽管以这种方式注射时，大部分肽不会到达肾上腺髓质，而是沿着主动脉向下传递。据计算，1分子缓激肽释放的儿茶酚胺分子数必须至少在50个区域，1分子血管紧张素释放的儿茶酚胺分子数必须在数千个区域。当静脉注射到未取出内脏的麻醉罐中时，用10 [mu]g缓激肽和0.1 [mu]g血管紧张素获得了释放髓质激素的证据。与缓激肽相关的两种激肽经腹腔动脉注入肾上腺髓质后释放出儿茶酚胺。一种是一点点，另一种是几百倍，比缓激肽活性低。它们对离体平滑肌制剂的作用具有相同的相对效力。加压素、催产素和P物质经腹腔动脉注射后，肾上腺髓质中的儿茶酚胺无释放。
When injected into the central stump of the coeliac artery of an eviscerated cat, anesthetized with chloralose, bradykinin and angiotensin were found to be potent releasers of the medullary hormones from the suprarenal glands, as evidenced by the ensuing contractions of the denervated nictitating membrane and the blood-pressure changes. The threshold dose for bradykinin varied between 0.05 and 1 /ig; with angiotensin a release of adrenaline was sometimes detected with as little as 1 -2 ng. Bradykinin released as much as its own weight, and angiotensin sometimes as much as a hundred times its own weight, or catecholamines when injected through the coeliac artery, although when injected in this way much of the peptide does not reach the suprarenal medulla, but passes down the aorta. It was calculated that the number of molecules of catechol amines released by 1 molecule of bradykinin must be at least in the region of 50, and by 1 molecule of angiotensin in the region of several thousands. When injected intravenously into a non-eviscerated anesthetized can evidence for the release of the medullary hormones was obtained with 10 [mu]g of bradykinin and with 0.1 [mu]g of angiotensin. Two kinins related to bradykinin released the catechol amines from the suprarenal medulla when injected through the coeliac artery. One was a little, the other several hundred times, less active than bradykinin. About the same relative potency pertained for their action on isolated smooth muscle preparations. No relaease of catechol amines from the suprarenal medulla was obtained with vasopressin, oxytocin and substance P when injected through the coeliac artery.