The Role of β2-Adrenergic Receptors in Inflammation and Allergy
The Role of β2-Adrenergic Receptors in Inflammation and Allergy
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DOI：
10.2174/1568010053586309
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
B. Šitkauskienė;R. Sakalauskas
中科院分区：
文献类型：
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作者：
B. Šitkauskienė;R. Sakalauskas
β(2)-肾上腺素受体（β (2)AR）在气道松弛中的重要作用已得到证实。然而，β (2)AR似乎在过敏和炎症中发挥了实际作用。β (2)AR与气道平滑肌促炎细胞因子的相互作用已被揭示。β (2) ar位于促炎细胞上，在体内可能影响这些细胞的功能。很明显，刺激β (2)AR抑制肥大细胞的促炎介质的释放，影响t细胞的生长和功能，嗜酸性粒细胞的存活和功能，包括GM-CSF或paf诱导的脱颗粒。刺激位于肺泡巨噬细胞和上皮细胞上的β (2)ARs，对它们在体内的调节和功能（包括吞噬和介质分泌）有不明确的影响。血管反应导致血浆渗出的抑制已被证实，但通过β (2)AR调节感觉神经尚不确定。β (2) ar激动剂对治疗即时过敏反应有效，但对炎症细胞的β (2) ar脱敏可能导致矛盾的效果，特别是在哮喘中。总之，很明显β (2) ar在体外可能具有抗炎作用。不幸的是，体外数据显示在体内的适用性有限；因此，这一领域还需要进一步的研究。
: Essential role of beta(2)-adrenoreceptor (beta(2)AR) in airway relaxation is well established. Nevertheless, beta(2)AR seems playing an actual role in allergy and inflammation. Interaction between beta(2)AR and proinflamatory cytokines in airway smooth muscle has been revealed. Being located on proinflamatory cells, beta(2)ARs may influence function of these cells in vivo. It was clear established, that stimulation of beta(2)AR inhibits release of proinflamatory mediators from mast cells, influences T-cell growth and function, eosinophil survival and function, including GM-CSF- or PAF-induced degranulation. Stimulation of beta(2)ARs, located on alveolar macrophages and epithelial cells, has ambiguity influence on their regulation and function, including phagocytosis and mediator secretion, in vivo. Vascular responses, resulting in inhibition of plasma exudation were confirmed, but modulation of sensory nerves via beta(2)AR is not certain yet. beta(2)AR-agonists are effective in treatment of immediate allergic reactions, but desensitisation of beta(2)ARs on inflammatory cells may result in paradoxical effects, especially in asthma. In summary, it is clear that beta(2)ARs may play an anti-inflammatory role in vitro. Unfortunately, in vitro data have shown limited applicability in vivo; therefore further research in this field is required.