Blocking interleukin-1 in rheumatic diseases.
Blocking interleukin-1 in rheumatic diseases.
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DOI：
10.1111/j.1749-6632.2009.05159.x
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发表时间：
2009-12
影响因子：
5.2
通讯作者：
Goldbach-Mansky R
中科院分区：
文献类型：
--
作者：
Goldbach-Mansky R
随着IL-1阻断剂阿那白滞素（Kineret®）（一种重组IL-1受体拮抗剂）的开发，可以在临床上研究强效促炎细胞因子IL-1在疾病中的作用。它首先在败血症患者中进行了测试，没有太大的益处，但后来FDA批准用于治疗类风湿性关节炎患者。最近，IL-1阻断疗法被成功地用于治疗一组新的免疫介导的炎性病症，即自身炎性疾病。这些条件包括罕见的遗传性发热综合征和儿童和成人条件的斯蒂尔病。最近，FDA批准了另外两种长效IL-1阻断剂，用于治疗cryopyrin相关周期性综合征（CAPS），一种IL-1依赖性自身炎症综合征。对自身炎症性疾病的研究揭示了IL-1介导的器官损伤机制，并为更好地了解痛风和2型糖尿病等更常见疾病的发病机制提供了概念，这些疾病通过IL-1阻断治疗显示出初步有希望的结果。
The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret®), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of patients with rheumatoid arthritis. More recently IL-1 blocking therapies are used successfully to treat a new group of immune-mediated inflammatory conditions, autoinflammatory diseases. These conditions include rare hereditary fever syndromes and pediatric and adult conditions of Still’s disease. Recently the FDA approved two additional longer acting IL-1 blocking agents, for the treatment of cryopyrin-associated periodic syndromes (CAPS), an IL-1 dependent autoinflammatory syndrome. The study of autoinflammatory diseases revealed mechanisms of IL-1 mediated organ damage and provided concepts to a better understanding of the pathogenesis of more common diseases such as gout and Type 2 diabetes which show initial promising results with IL-1 blocking therapy.
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影响因子：
27.4
作者：
Godinho, FMV;Santos, MJP;da Silva, JC
通讯作者：
da Silva, JC
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R
影响因子：
--
作者：
Gattorno, Marco;Piccini, Alessandra;Rubartelli, Anna
通讯作者：
Rubartelli, Anna
影响因子：
--
作者：
Cohen, S;Hurd, E;McCabe, D
通讯作者：
McCabe, D
影响因子：
120.7
作者：
FISHER, CJ;DHAINAUT, JFA;STABLEIN, D
通讯作者：
STABLEIN, D