Linear IgA disease and ulcerative colitis
Linear IgA disease and ulcerative colitis
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线性 IgA 疾病和溃疡性结肠炎
DOI：
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发表时间：
1997
影响因子：
10.3
通讯作者：
Lionel Fry
中科院分区：
文献类型：
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作者：
D. G. Paige;Jonathan N. Leonard;F. Wojnarowska;Lionel Fry
本文对70例成人线性IgA病患者进行了研究。5人(7.1%)还患有溃疡性结肠炎(溃疡性结肠炎在英国的患病率为0.05%)。来自其他英国中心的另外三名与此相关的患者也进行了审查。在所有病例中，溃疡性结肠炎的发病时间比皮肤病平均早6.5年。这种联系的原因尚不清楚，但已报道的溃疡性结肠炎患者结肠粘膜B细胞和粘膜IgA1产生的异常可能在IgA1介导的线性IgA疾病的后续发展中起重要作用。
Seventy adult patients with linear IgA disease were studied. Five (7.1%) also suffered from ulcerative colitis (the prevalence of ulcerative colitis in the U.K. is 0.05%). A further three patients with this association, from other British centres were also reviewed. In all cases, ulcerative colitis preceded the onset of skin disease, by a median of 6.5 years. The reason for this association remains unclear but the abnormalities in colonic mucosal B cells and mucosal IgA1 production reported in patients with ulcerative colitis may be important in the subsequent development of IgA1 mediated linear IgA disease.