Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma
Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma
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DOI：
10.1002/jso.21001
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Prasad, K. Rajendra
中科院分区：
文献类型：
--
作者：
Gomez, Dhanwant;Morris-Stiff, Gareth;Prasad, K. Rajendra
目的：分析肝内胆管癌（IHCC）潜在治愈性切除术后的结果和影响无病生存和总生存的预后因素。方法：纳入 1996 年 1 月至 2006 年 12 月接受 IHCC 切除的患者。分析的数据包括人口统计、临床和组织病理学数据。结果：27 名患者的中位年龄为 57 (32-84) 岁。 1年、3年和5年总生存率和无病生存率分别为74%、16%和16%，以及44%、15%和15%。在单变量分析中，年龄 = 5、微血管侵犯和淋巴结受累是总体生存率较差的预测因素。多变量分析没有发现任何独立的总体生存预测因子。 NLR >= 5 是无病生存的唯一不利预测因子。 NLR >= 5 患者的中位无病生存期为 6 个月，而 NLR < 5 患者的中位无病生存期为 18 个月。NLR >= 5 的患者与较大的肿瘤、卫星病变、微血管侵犯和淋巴结受累之间存在显着相关性。结论：IHCC 切除后的长期结果较差。术前 NLR >= 5 是无病生存的不利预测因素，并且与侵袭性肿瘤生物学特征相关。
Aims: To analyse the results and prognostic factors affecting disease-free and overall survival following potentially curative resection for intrahepatic cholangiocarcinoma (IHCC).Methods: Patients undergoing resection for IHCC from January 1996 to December 2006 were included. Data analysed included demographics, clinical and histopathology data.Results: Twenty-seven patients were identified with a median age of 57 (32-84) years. The 1-, 3- and 5-year overall and disease-free survival rates were 74%, 16% and 16%, and 44%, 15% and 15%, respectively. On univariate analysis, age = 5, micro-vascular invasion and lymph node involvement were predictors of poorer overall survival. Multivariate analysis did not identify any independent predictors of overall survival. A NLR >= 5 was the only adverse predictor of disease-free survival. The median disease-free survival of patients with NLR >= 5 was 6 months compared to 18 months for those with NLR < 5. There was a significant association between patients with a NLR >= 5 and larger turnout size, satellite lesions, micro-vascular invasion and lymph node involvement.Conclusion: Long-term outcome following resection of IHCC is poor. A pre-operative NLR >= 5 was an adverse predictor of disease-free survival and was associated with an aggressive tumour biology profile.