Ethanol's behavioral effects may be partly due to increases in brain prostaglandin production.
Ethanol's behavioral effects may be partly due to increases in brain prostaglandin production.
复制标题
乙醇对行为的影响可能部分归因于大脑前列腺素生成的增加。
DOI：
10.1111/j.1530-0277.1985.tb05539.x
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Collins,AC
中科院分区：
文献类型：
--
作者：
George,FR;Collins,AC
前列腺素合成抑制剂拮抗对乙醇的行为反应。阻止乙醇作用所需的抑制剂（例如吲哚美辛或阿司匹林）的剂量与生物体的乙醇敏感性成正比。针对乙醇差异反应而选择性培育的动物为探索乙醇相关行为的生化底物提供了有用的工具。这项研究表明，乙醇以剂量、性别和基因型依赖的方式增加大脑前列腺素水平，这与乙醇部分作用机制是增加前列腺素产生的假设一致。
Prostaglandin synthesis inhibitors antagonize behavioral responses to ethanol. The dose of inhibitor (e.g., indomethacin or aspirin) required to block ethanol's effects is directly proportional to the ethanol sensitivity of the organism. Animals selectively bred for differential response to ethanol provide a useful tool in exploring the biochemical substrates of ethanol‐related behavior. This study snows that ethanol increases brain prostaglandin levels in a dose‐, sex‐, and genotype‐dependent manner consistent with the hypothesis that part of ethanol's mechanism of action is to increase the production of prostaglandins.