Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis
Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis
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DOI：
10.14670/hh-11-721
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发表时间：
2016-08-01
影响因子：
2
通讯作者：
Ohashi, Kenichi
中科院分区：
文献类型：
--
作者：
Okudela, Koji;Mitsui, Hideaki;Ohashi, Kenichi
本文分析了原肌球蛋白表达水平与临床病理因素之间的关系，以确定原肌球蛋白在肺癌中的意义。虽然肿瘤细胞表达不同亚型的原肌球蛋白，总体表达水平低于支气管和肺泡上皮细胞。在腺癌中，原肌球蛋白水平在低分化或实体亚型癌中显著降低，表明原肌球蛋白表达的丧失与肺腺癌的进展有关。还研究了原肌球蛋白的免疫组织化学表达用于组织病理学诊断的潜在效用。原肌球蛋白表达缺失的敏感性和特异性分别为100%和50%，优于常规生物标志物p53的强表达（敏感性100%，特异性44%）。原肌球蛋白的免疫组化检查可能有助于小活检标本中肺癌细胞的组织病理学检测。
We herein analyzed the relationships between tropomyosin protein expression levels and clinicopathological factors in order to determine the significance of tropomyosins in lung cancers. Although neoplastic cells expressed different isoforms of tropomyosin, overall expression levels were lower than those in bronchial and alveolar epithelial cells. In adenocarcinomas, tropomyosin levels were markedly reduced in poorly differentiated or solid subtype carcinomas, suggesting that a loss in the expression of tropomyosins is involved in the progression of lung adenocarcinomas. The potential utility of the immunohistochemical expression of tropomyosins for a histopathological diagnosis was also investigated. The sensitivity and specificity of a loss in the expression of tropomyosins were 100% and 50%, respectively, which were superior to those for the strong expression of p53 (sensitivity 100% and specificity 44%), a conventional biomarker. An immunohistochemical examination of tropomyosins may assist in the histopathological detection of lung cancer cells in small biopsy specimens.