Heart rate dynamics after acute cocaine administration.
Heart rate dynamics after acute cocaine administration.
复制标题
急性可卡因给药后的心率动态。
DOI：
10.1097/00005344-199203000-00024
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发表时间：
1992
影响因子：
3
通讯作者：
Harper,RM
中科院分区：
文献类型：
--
作者：
Garfinkel,A;Raetz,SL;Harper,RM
We examined heart rate (HR) patterns after a bolus intravenous (iv) administration of a high (10 mg/kg) dose of cocaine in unrestrained cats. Mean RR intervals, SD, and other measures of variability were assessed in three periods: waking baseline, early postcocaine administration, and later recovery periods. Cocaine resulted in initial tachycardia and reduced HR variability. This reduction in variability was independent of changes in the average rate: during the recovery period, HR returned to baseline values, but the reduced variability persisted. Nonlinear methods of assessment yielded additional results: Cocaine introduces a high correlation between one beat and the next and a tendency for cardiac accelerations to be followed immediately by decelerations and vice versa. The overall effect of the drug is to restrict deviation from a fixed rate.
