Mitotic crisis The unmasking of a novel role for RPA
Mitotic crisis The unmasking of a novel role for RPA
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DOI：
10.4161/cc.8.3.7496
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发表时间：
2009-02-01
期刊：
影响因子：
4.3
通讯作者：
Borowiec, James A.
中科院分区：
文献类型：
--
作者：
Anantha, Rachel William;Borowiec, James A.
有丝分裂DNA损伤是对基因组完整性的持续威胁，但对这种应激的细胞反应的理解仍然不完整。Anantha等人（2008; PNAS 105：12903-8）的最近工作已经发现了令人惊讶的证据，即RPA（主要的真核单链DNA结合蛋白）可以刺激细胞退出有丝分裂进入2NG（1）期的能力。沿着本研究的额外讨论，我们回顾证据表明，DNA复制和修复因子可以通过Polo样激酶-1（Plk 1）和中心体调节有丝分裂转运。“危机暴露了每个人。- -梅森·库利，美国大学S.警句
Mitotic DNA damage is a constant threat to genomic integrity, yet understanding of the cellular responses to this stress remain incomplete. Recent work by Anantha et al. (2008; PNAS 105: 12903-8) has found surprising evidence that RPA, the primary eukaryotic single-stranded DNA-binding protein, can stimulate the ability of cells to exit mitosis into a 2N G(1) phase. Along with providing additional discussion of this study, we review evidence suggesting that DNA replication and repair factors can modulate mitotic transit by acting through Polo-like kinase-1 (Plk1) and the centrosome.'A crisis unmasks everyone.'-Mason Cooley, U. S. aphorist.