Preeclampsia - A pressing problem: An executive summary of a national institute of child health and human development workshop
Preeclampsia - A pressing problem: An executive summary of a national institute of child health and human development workshop
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DOI：
10.1177/1933719107306232
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发表时间：
2007-09-01
影响因子：
2.9
通讯作者：
Roberts, James M.
中科院分区：
文献类型：
--
作者：
Ilekis, John V.;Reddy, Uma M.;Roberts, James M.
2006年9月21日和22日，美国国立卫生研究院国家儿童健康和人类发展研究所主办了一个为期两天的题为“先兆子痫-一个紧迫的问题”的研讨会。“研讨会的目的是汇集该领域的领导者，介绍和讨论他们不同的研究领域，从基础科学到临床试验和管理，并确定科学差距。本文是该研讨会的会议纪要.虽然在了解先兆子痫的基础方面取得了很大进展，但仍存在一些研究空白，如果填补这些空白，将加速该领域的进展。总体共识是，先兆子痫是一种多因素疾病，其发病机制不仅仅是血管、遗传、免疫或环境因素，而是多种因素的复杂组合。此外，还发现了一些具体的科学差距，包括多学科和协作研究、临床试验和患者管理研究不足，以及缺乏深入的机制研究。研究界需要关注这些差距，以更好地了解这种疾病，最终目标是预防这种疾病。
On September 21 and 22, 2006, the National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled "Preeclampsia - A Pressing Problem." The purpose of the workshop was to bring together leaders in the field to present and discuss their diverse research areas, which ranged from basic science to clinical trials and management, and to identify scientific gaps. This article is a summary of the proceedings that workshop. Although much progress is being made in understanding the underpinnings of precclampsia, a number of research gaps are identified that, if filled, would hasten progress in the field. It is the overall consensus that preeclampsia is a multifactorial disease whose pathogenesis is not solely vascular, genetic, immunologic, or environmental but a complex combination of factors. In addition, a number of specific scientific gaps are identified including insufficient multidisciplinary and collaborative research, clinical trials and studies of patient management, and a lack of in-depth mechanistic research. The research community needs to focus on these gaps to better understand the disease, with the ultimate goal of preventing the disorder.