Implications of the International Society of Urological Pathology Modified Gleason Grading System
Implications of the International Society of Urological Pathology Modified Gleason Grading System
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DOI：
10.5858/arpa.2011-0495-ra
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发表时间：
2012-04-01
影响因子：
4.6
通讯作者：
Montironi, Rodolfo
中科院分区：
文献类型：
--
作者：
Egevad, Lars;Mazzucchelli, Roberta;Montironi, Rodolfo
背景。-组织学分级是临床上最有用的基于组织的前列腺癌预后预测因子。多年来，格里森分级在实践中的应用逐渐发生了变化，总体趋势是升级。国际泌尿病理学会（ISUP）于2005年组织了一次共识会议，以标准化组织学模式的感知以及如何编辑和编辑等级信息。回顾ISUP改良格里森分级系统的含义。数据来源。个人经验和审查目前的文献。结论。总结了有关模式解释和报告的建议。ISUP修改格里森分级的实际后果的报告。Gleason评分的预后重要性，其再现性，其术前评估进行了讨论。随后的建议略有修改的ISUP分级系统进行说明。(Arch Pathol Lab Med. 2012; 136：426-434; doi：10.5858/arpa.2011-0495-RA）
Context.-Histologic grading is the clinically most useful tissue-based predictor of prognosis for prostate cancer. Over the years, there has been a gradual shift in how the Gleason grading is applied in practice, with a general trend toward upgrading. A consensus conference was organized in 2005 by the International Society of Urological Pathology (ISUP) for standardizing both the perception of histologic patterns and how the grade information is compiled and reported.Objective.-To review the implications of the ISUP modified Gleason grading system.Data Sources.-Personal experience and review of the current literature.Conclusions.-The recommendations regarding pattern interpretation and reporting are summarized. The practical consequences of the ISUP modification of the Gleason grading are reported. The prognostic importance of the Gleason score, its reproducibility, and its preoperative assessment are discussed. Subsequent proposals for slight modifications to the ISUP grading system are described. (Arch Pathol Lab Med. 2012; 136:426-434; doi: 10.5858/arpa.2011-0495-RA)