Hydrophobic Organic Components of Ambient Fine Particulate Matter (PM2.5) Associated with Inflammatory Cellular Response
Hydrophobic Organic Components of Ambient Fine Particulate Matter (PM2.5) Associated with Inflammatory Cellular Response
复制标题
环境细颗粒物 (PM2.5) 的疏水性有机成分与炎症细胞反应相关
DOI：
10.1021/acs.est.9b02902
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发表时间：
2019-09-03
影响因子：
11.4
通讯作者：
Zhu, Tong
中科院分区：
文献类型：
--
作者：
Jiang, Xing;Xu, Fanfan;Zhu, Tong
Nowadays, knowledge regarding component specific inflammatory effect of fine particulate matter (PM2.5) is limited. In this study, an omics approach based on time-of flight mass spectrometry was established to identify the key hydrophobic components of PM2.5 associated with pro inflammatory cytokines released by macrophages after in vitro exposure. Of 764 compounds, 62 components were robustly screened with firmly identified 37 specific chemicals. In addition to polycyclic aromatic hydrocarbons (PAHs) and their methylated congeners, novel oxygen- and nitrogen-containing PAHs and, especially, oxygenated PAHs (Oxy-PAHs) were identified. Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1 beta and tumor necrosis factor (TNF)-alpha were with most species. Most species were related to IL-1 beta, which was significantly higher in the heating season, with a monotonic dose-response pattern mainly for Oxy-PAHs and a U-shaped dose-response pattern for primary species. On the basis of the identified components, four sources of pollution (coal combustion, traffic emissions, biomass burning, and secondary formation, traced by Oxy-PAHs such as 1,8-naphthalic anhydride and quinones) were resolved by the positive matrix factorization model. TNF-alpha was associated with primary sources, whereas IL-1 beta and IL-6 were associated with both primary and secondary sources, suggesting different inflammatory effects between primary and secondary sources when assessing the toxicity-driven disparities of known and unknown PM2.5 components.
