Two new sesquiterpenes derivatives from marine fungus Leptosphaerulina Chartarum sp 3608
Two new sesquiterpenes derivatives from marine fungus Leptosphaerulina Chartarum sp 3608
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来自海洋真菌 Leptosphaerulina Chartarum sp 3608 的两种新倍半萜衍生物
DOI：
10.1080/14786419.2017.1408102
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发表时间：
2018
影响因子：
2.2
通讯作者：
Liu Lan
中科院分区：
文献类型：
--
作者：
Zhang Panpan;Li Jing;Lang Jiajia;Jia Chunxiu;Niaz Shah-Iram;Chen Senhua;Liu Lan
从螺旋藻Leptosphaerulina Chartarumsp.中分离得到两个新的倍半萜化合物，分别为细叶松萜A(1)和B(2)。3608，源自一颗蛇床子叶。这是对该物种进行的第一次化学研究。通过核磁共振、质谱学等波谱方法对化合物的结构进行了鉴定。通过单晶X射线衍射法和电子圆二色谱数据分析确定了新化合物的绝对构型。测试了所有化合物的抗炎活性和对酪氨酰DNA磷酸二酯酶II(TDP2)的抑制作用。
Two new sesquiterpenes, leptoterpenes A (1) and B (2) were isolated from the fungusLeptosphaerulina Chartarumsp. 3608, derived from a crinoid. It was the first chemical study on this species. The structures of these compounds were elucidated by spectroscopic methods including NMR and MS spectrometry. The absolute configurations of the new compounds were determined on the basis of the single-crystal X-ray diffraction and electronic circular dichroism data analysis. All compounds were tested for their anti-inflammatory activity and the inhibitory effects on Tyrosyl DNA phosphodiesterase II (TDP2).